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olivLaw · US equity research

Allogene Therapeutics, Inc. ALLO

Biological Products, (No Diagnostic Substances) · SIC 2836 · Vertical: Biological Products, (No Diagnostic Substances) (SIC 2836)

1.19USD+6.25% · 1 dayClose 04 Nov 2026

Allogene Therapeutics develops allogeneic 'off-the-shelf' CAR T therapies for cancer and autoimmune disease, with its pivotal ALPHA3 program in first-line large B-cell lymphoma now in focus. The 2026 interim futility analysis showed a higher MRD negativity rate in the cema-cel arm, which keeps investors and specialists watching the program closely.

At the close of 04 Nov 2026, Allogene Therapeutics, Inc. (ALLO) stock was 1.19 USD (+6.25% on the day), with market capitalisation 411.1 m USD, dividend yield 0.00%, beta 1.57, 52-week range 1.05–3.06 USD. Latest reported quarter (Q2 2026): revenue of 4.6 m USD, net income of -42.7 m USD, diluted EPS -0.13 USD.

Data as of · AI analysis dated · Source: SEC filings and closing prices, computed by olivLaw.

Market cap
411.1 m USD
shares as of 10 Aug 2026
P/E (TTM)
unavailable
Diluted EPS TTM -0.67 · TTM to 30 Jun 2026
E/P (TTM)
-56.45%
TTM to 30 Jun 2026
Dividend yield
0.00%
DPS 12m 0.00
Beta (2y)
1.57
Volatility (1y) 83%
52-week range
1.053.06

Price history

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Technical reading

RSI (14)
36.8
weak (30–45)
Bollinger (20, 2)
1.10 – 1.46
in the lower half of the band · %B 0.26 · band width 28.2%
SMA 50 / 200
1.56 / 1.97
downtrend (price < SMA50 < SMA200)
MACD (12, 26, 9)
-0.11 / -0.12
MACD above signal

Indicators describe past prices; on their own they do not predict direction. On our history the RSI ≤ 40 filter added no return (see the signals methodology).

Performance

CompanyS&P 500vs S&P 500Vertical median
1 month−20.7%−1.1%−19.6 pp—
3 months−39.0%−0.5%−38.5 pp—
6 months−48.5%+4.4%−52.9 pp—
Year to date−13.1%+12.3%−25.5 pp—
1 year+7.2%+13.5%−6.3 pp+5.3%
3 years−66.0%+76.4%−142.4 pp−6.6%
5 years−94.1%+63.7%−157.8 pp—
Max drawdown (1y)
−64.4%
13 Apr 2026 → 02 Nov 2026
Max drawdown (5y)
−95.2%
08 Nov 2021 → 14 May 2025
Compound annual growth (5y)
−43.2%
S&P 500 +10.4%

Price returns, dividends excluded.

Quarterly results

Latest quarter: Q2 2026 · 30 Jun 2026

Revenue
4.6 m USD
unavailable YoY
Net income
-42.7 m USD
unavailable YoY
Diluted EPS
-0.13
unavailable YoY
net / operating
-919.8% / -1,011.2%

Quarterly margins

Quarterly statements · USD

Fiscal yearQ3 '24Q4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26Q2 '26
Revenue000000—4.6 m
Research & development44.7 m45.0 m50.2 m40.2 m31.2 m28.6 m32.0 m30.7 m
Operating income-71.8 m-60.5 m-65.2 m-56.8 m-44.9 m-42.4 m-46.1 m-46.9 m
Depreciation & amortisation3.2 m ≈3.2 m3.1 m3.1 m ≈3.1 m ≈3.1 m2.9 m2.6 m ≈
Interest expense100.0 k81.0 k150.0 k268.0 k344.0 k313.0 k300.0 k343.0 k
Net income-66.3 m-59.9 m-59.7 m-50.9 m-41.4 m-38.8 m-42.6 m-42.7 m
Diluted EPS-0.32-0.28 ≈-0.28-0.23-0.19-0.17 ≈-0.18-0.13
Operating cash flow-44.1 m ≈-36.7 m-52.9 m-39.0 m ≈-29.7 m ≈-27.6 m-12.9 m-32.0 m ≈
Capex429.0 k ≈257.0 k99.0 k44.0 k ≈243.0 k ≈09.0 k150.0 k ≈

≈ derived quarter (cumulative difference / share-days average)

E/P over time

E/P = trailing-12-month diluted EPS / price at quarter end. E/P is the inverse of P/E and stays defined when earnings are negative.

Fiscal years

Fiscal year20182019202020212022202320242025
Revenueunavailable00114.1 m156.0 k95.0 k22.0 k0
Revenue YoYunavailableunavailableunavailableunavailable−99.9%−39.1%−76.8%−100.0%
Net income-211.5 m-184.6 m-316.4 m-182.1 m-340.4 m-327.3 m-257.6 m-190.9 m
Net income YoYunavailableunavailableunavailableunavailableunavailableunavailableunavailableunavailable
Diluted EPSunavailable-1.83-2.63-1.34-2.38-2.09-1.32-0.87
Diluted EPS YoYunavailableunavailableunavailableunavailableunavailableunavailableunavailableunavailable
net %unavailableunavailableunavailable-159.6%-218,214.1%-344,489.5%-1,170,863.6%unavailable
Free cash flow-47.9 m-188.1 m-181.1 m-206.3 m-225.7 m-239.2 m-201.0 m-149.6 m

Reported results vs expectations

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Balance sheet & financial health

Fiscal year 2025 · 31 Dec 2025

Cash
51.7 m USD
Financial debt
unavailable USD
Net debt
unavailable USD
Equity
292.5 m USD
Total assets
415.9 m USD
Debt / equity
unavailable
Current ratio
7.93x
ROE
-53.4%
ROA
-39.6%
FCF margin
unavailable

Financial statements (source on every figure)

Revenue and net income (USD)

Margins

Income statement · USD

Revenue
2023
95.0 k
2024
22.0 k
2025
0

SEC (XBRL)· 12 Mar 2026verified

Research & development
2023
242.9 m
2024
192.3 m
2025
150.2 m

SEC (XBRL)· 12 Mar 2026verified

Operating income
2023
-327.7 m
2024
-273.2 m
2025
-209.3 m

SEC (XBRL)· 12 Mar 2026verified

Depreciation & amortisation
2023
14.2 m
2024
13.6 m
2025
12.4 m

SEC (XBRL)· 12 Mar 2026verified

EBITDA
2023
-313.5 m ≈
2024
-259.6 m ≈
2025
-197.0 m ≈

SEC (XBRL)· 12 Mar 2026derived

Interest expense
2023
0
2024
181.0 k
2025
1.1 m

SEC (XBRL)· 12 Mar 2026verified

Pre-tax income
2023
-327.3 m
2024
-257.1 m
2025
-190.9 m

SEC (XBRL)· 12 Mar 2026verified

Income tax
2023
0
2024
443.0 k
2025
0

SEC (XBRL)· 12 Mar 2026verified

Net income
2023
-327.3 m
2024
-257.6 m
2025
-190.9 m

SEC (XBRL)· 12 Mar 2026verified

Diluted EPS
2023
-2.09
2024
-1.32
2025
-0.87

SEC (XBRL)· 12 Mar 2026verified

Weighted average diluted shares
2023
156.9 m
2024
194.8 m
2025
220.6 m

SEC (XBRL)· 12 Mar 2026verified

Dividend per share
2023
0.00
2024
0.00
2025
0.00

SEC (XBRL)· 12 Mar 2026verified

Balance sheet · USD

Cash
2023
83.2 m
2024
75.2 m
2025
51.7 m

SEC (XBRL)· 12 Mar 2026verified

Current assets
2023
459.1 m
2024
303.4 m
2025
257.7 m

SEC (XBRL)· 12 Mar 2026verified

Property, plant & equipment, net
2023
99.5 m
2024
86.1 m
2025
72.8 m

SEC (XBRL)· 12 Mar 2026verified

Intangibles (excl. goodwill)
2023
—
2024
—
2025
—

SEC (XBRL)· 25 Feb 2021verified

Total assets
2023
642.8 m
2024
548.7 m
2025
415.9 m

SEC (XBRL)· 12 Mar 2026verified

Accounts payable
2023
5.9 m
2024
5.4 m
2025
4.3 m

SEC (XBRL)· 12 Mar 2026verified

Current liabilities
2023
37.1 m
2024
35.5 m
2025
32.5 m

SEC (XBRL)· 12 Mar 2026verified

Total liabilities
2023
130.6 m
2024
126.5 m
2025
123.4 m

SEC (XBRL)· 12 Mar 2026verified

Equity
2023
512.2 m †
2024
422.2 m †
2025
292.5 m †

SEC (XBRL)· 12 Mar 2026verified

Cash flow · USD

Operating cash flow
2023
-237.7 m
2024
-200.3 m
2025
-149.2 m

SEC (XBRL)· 12 Mar 2026verified

Capex
2023
1.5 m
2024
694.0 k
2025
386.0 k

SEC (XBRL)· 12 Mar 2026verified

Free cash flow
2023
-239.2 m ≈
2024
-201.0 m ≈
2025
-149.6 m ≈

SEC (XBRL)· 12 Mar 2026derived

Investing cash flow
2023
163.3 m
2024
75.7 m
2025
95.6 m

SEC (XBRL)· 12 Mar 2026verified

Financing cash flow
2023
95.7 m
2024
116.7 m
2025
30.2 m

SEC (XBRL)· 12 Mar 2026verified

Computed indicators

Growth

Revenue growth (YoY)
-100.0%
computed by olivLawFY 2025
Revenue CAGR 3Y
unavailable
the base of the ratio is not positive
Revenue CAGR 5Y
unavailable
the base of the ratio is not positive
EBIT growth (YoY)
unavailable
the base of the ratio is not positive
Net income growth (YoY)
unavailable
the base of the ratio is not positive
Net income CAGR 3Y
unavailable
the base of the ratio is not positive
Net income CAGR 5Y
unavailable
the base of the ratio is not positive
EPS growth (YoY)
unavailable
the base of the ratio is not positive
EPS CAGR 3Y
unavailable
the base of the ratio is not positive
EPS CAGR 5Y
unavailable
the base of the ratio is not positive
FCF growth (YoY)
unavailable
the base of the ratio is not positive

Profitability

Gross margin
unavailable
input data missing
EBITDA margin
-3,634.7%
computed by olivLawTTM to 30 Jun 2026
EBIT margin
-3,886.1%
computed by olivLawTTM to 30 Jun 2026
Net margin
-3,566.7%
computed by olivLawTTM to 30 Jun 2026
FCF margin
-2,211.2%
computed by olivLawTTM to 30 Jun 2026

Returns

ROE
-42.4%
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
ROA
-32.4%
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
ROIC
unavailable
input data missing
ROCE
-34.8%
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
Payout ratio (EPS)
unavailable
insufficient data
Payout ratio (FCF)
unavailable
input data missing

Balance sheet

Net debt
unavailable
input data missing
Net debt / EBITDA
unavailable
input data missing
Debt / equity
unavailable
input data missing
Interest coverage
-138.7x
computed by olivLawTTM to 30 Jun 2026

Liquidity

Current ratio
10.7x
computed by olivLawbalance sheet at 30 Jun 2026
Quick ratio
unavailable
input data missing
Cash ratio
1.2x
computed by olivLawbalance sheet at 30 Jun 2026

Cash

Operating cash flow
-102.2 m USD
computed by olivLawTTM to 30 Jun 2026
Capital expenditure
402.0 k USD
computed by olivLawTTM to 30 Jun 2026
Free cash flow
-102.6 m USD
computed by olivLawTTM to 30 Jun 2026
FCF conversion
unavailable
insufficient data
Cash conversion
unavailable
insufficient data

Efficiency

Days sales outstanding
unavailable
input data missing
Days inventory outstanding
unavailable
input data missing
Days payables outstanding
unavailable
input data missing
Cash conversion cycle
unavailable
input data missing

Market and valuation

Market capitalisation
411.1 m USD
computed by olivLawbalance sheet at 30 Jun 2026
Enterprise value
unavailable
input data missing
Market cap / net income TTM
unavailable
insufficient data
P/E (TTM)
unavailable
insufficient data
Earnings yield
-56.4%
computed by olivLawTTM to 30 Jun 2026
P/B
0.9x
computed by olivLawbalance sheet at 30 Jun 2026
P/S
88.6x
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
EV/EBITDA
unavailable
input data missing
EV/EBIT
unavailable
input data missing
EV/Sales
unavailable
input data missing
P/FCF
unavailable
the base of the ratio is not positive
FCF yield
-25.0%
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
Dividend yield
0.0%
computed by olivLawTTM to 30 Jun 2026
Shareholder yield (distributions)
unavailable
input data missing

1 indicators that do not apply to the sector.

Valuation

olivLaw classification

Insufficient data
What is missing
  • indicators available: 4 of at least 6
  • score weight coverage: 25.0% of at least 60%
  • valuation methods computed: 0 of at least 1

A scoring methodology on indicators and valuation, not investment advice.

Closing price

1.19 USD

04 Nov 2026Source: olivLaw, closing series

Market cap: 411.1 m USD

Key indicators

Market capitalisation
411.1 m USD
computed by olivLawbalance sheet at 30 Jun 2026
P/E (TTM)
unavailable
insufficient data
P/B
0.9x
computed by olivLawbalance sheet at 30 Jun 2026
EV/EBITDA
unavailable
input data missing
ROE
-42.4%
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
Net margin
-3,566.7%
computed by olivLawTTM to 30 Jun 2026
Revenue growth (YoY)
-100.0%
computed by olivLawFY 2025
Dividend yield
0.0%
computed by olivLawTTM to 30 Jun 2026

Coverage and freshness

26/37 reporting lines present
Latest full fiscal year: 2025
Latest reported period: 30 Jun 2026
Latest balance sheet date: 30 Jun 2026
Share count (cover of the latest filing), as of: 10 Aug 2026
Source: SEC (XBRL)published 12 Aug 2026
verified 924derived 74

Score by group

25% · Insufficient data

Estimated value range

unavailable — no valuation method could be computed

Valuation assumptions are editorial choices, not measured; beta is not measured.

Valuation methods

  • DCF (discounted cash flow)unavailable · net debt missing: EV cannot be bridged to equity (missing debt is not zero)
  • Peers: EV/EBITDAunavailable · net debt missing: EV cannot be bridged to equity (missing debt is not zero)
  • Peers: P/Eunavailable · the base of the ratio is not positive
  • Dividend discount (DDM)unavailable · the base of the ratio is not positive

no valuation method could be computed

Multiple comparisons use the SIC vertical: Biological Products, (No Diagnostic Substances) (SIC 2836)

Classification (SIC) comparables group by industry code, not by economic activity; the direct group is an editorial selection by activity. Members' multiples are on their own trailing twelve months, at their own latest close.

Assumptions (illustrative, editorial)

Risk-free rate
4.3%
Equity risk premium
5.0%
Beta (default)
1.00
Cost of equity
9.3%
Terminal growth
2.5%

Factor scorecard

Insufficient data

Minimum-evidence gate: indicators available: 4 of at least 6; score weight coverage: 25.0% of at least 60%; valuation methods computed: 0 of at least 1

FactorValueScoreWeight used
ROIC · Qualityunavailableunavailable—
Net margin · Quality-3,566.7%21 (vs peers)25%
FCF conversion · Qualityunavailableunavailable—
Revenue CAGR 3Y · Growthunavailableunavailable—
EPS CAGR 3Y · Growthunavailableunavailable—
Net debt / EBITDA · Balance sheetunavailableunavailable—
Interest coverage · Balance sheet-138.7x0 (on a fixed band)25%
Current ratio · Balance sheet10.7x100 (on a fixed band)17%
P/E (TTM) · Valuationunavailableunavailable—
EV/EBITDA · Valuationunavailableunavailable—
FCF yield · Valuation-25.0%0 (on a fixed band)33%
Shareholder yield (distributions) · Returnsunavailableunavailable—
Payout ratio (FCF) · Returnsunavailableunavailable—

Factors without a value were dropped; the remaining weights were renormalised.

Score groups

  • Balance sheet40/100 · 2/3 factors with a value
  • Growth· partialunavailable · 0/2 factors with a value
  • Quality· partial21/100 · 1/3 factors with a value
  • Returns· partialunavailable · 0/2 factors with a value
  • Valuation· partial0/100 · 1/3 factors with a value

A «partial» group is computed from under half of its weight or from one factor: it is not a full assessment of the group.

Memo

Allogene Therapeutics, Inc. (ALLO). Latest full fiscal year: 2025; data up to 2026-06-30.

Figures computed from the financial statements: revenue 0 USD in 2025; YoY growth -100.0%; net margin -3,566.7%; ROE -42.4%.

Valuation cannot be computed from the available data.

Insufficient data for a verdict (indicators available: 4 of at least 6; score weight coverage: 25.0% of at least 60%; valuation methods computed: 0 of at least 1).

Text generated deterministically from the figures shown; no language model. Not investment advice.

What supports the thesis

  • Current ratio: 10.7x

What contradicts it

  • Net margin: -3,566.7%
  • Interest coverage: -138.7x
  • FCF yield: -25.0%

Not assessed (insufficient data or a ratio without meaning): ROIC, FCF conversion, Revenue CAGR 3Y, EPS CAGR 3Y, Net debt / EBITDA, P/E (TTM), EV/EBITDA, Shareholder yield (distributions), Payout ratio (FCF).

Versus the vertical median

Biological Products, (No Diagnostic Substances) (SIC 2836) · same industry (4-digit SIC) · compared with 39 companies

Multiples and returns vs the median

P/E
—
vertical median 26.2x
EV/EBITDA
—
vertical median 19.6x
P/S
88.6x
vertical median 6.7x
above median (+1,231.9%)
P/B
0.9x
vertical median 4.0x
below median (−76.7%)
ROE
-42.4%
vertical median -53.5%
above median
Net margin
-3,566.7%
vertical median -194.7%
below median
EBIT margin
-3,886.1%
vertical median -212.5%
below median
Revenue YoY
-100.0%
vertical median 5.7%
below median (−1,869.8%)
Net debt/EBITDA
—
vertical median 2.7x
Dividend yield
0.0%
vertical median —

Price rebased to 100 (monthly, 5 years)

Companies in the vertical

Market capP/EROENet marginRevenue YoY1A / 3A
AMGNAmgen Inc.258.8 bn27.778.4%24.1%+10.0%+39% / +77%
GILDGilead Sciences, Inc.216.4 bn—-22.3%-12.5%+2.4%+39% / +128%
MRNAModerna, Inc.103.2 bn—-39.0%-141.4%−39.9%+895% / +233%
RVMDRevolution Medicines, Inc.43.2 bn—-93.6%-946.8%unavailable+157% / +756%
BIIBBiogen Inc.37.6 bn108.81.9%3.4%+2.2%+40% / +9%
EXELExelixis, Inc.17.8 bn21.744.3%35.5%+7.0%+65% / +234%
NBIXNeurocrine Biosciences, Inc.16.8 bn24.620.4%19.0%+21.4%+9% / +42%
HALOHalozyme Therapeutics, Inc.14.8 bn38.4173.7%24.9%+37.6%+83% / +238%
KYMRKymera Therapeutics, Inc.11.6 bn—-27.3%-341.8%−16.7%+101% / +556%
BEAMBeam Therapeutics Inc.2.9 bn—-11.3%-73.9%+120.0%+10% / −1%
BCRXBiocryst Pharmaceuticals, Inc.2.1 bn——-37.4%+94.1%+15% / +40%
MAZEMaze Therapeutics, Inc.1.9 bn—-37.3%-5,343.6%unavailable−12% / unavailable
ALVOAlvotech1.5 bn46.7—4.8%+19.7%−8% / −51%
CGEMCullinan Therapeutics, Inc.803.8 m—-50.3%—−100.0%+10% / +53%
CADLCandel Therapeutics, Inc.692.5 m—-81.8%—0.0%+90% / +907%
FDMT4D Molecular Therapeutics, Inc.611.3 m—-43.3%-194.7%+230,194.6%+5% / −3%
ATYRaTYR PHARMA INC606.2 m—-98.4%-32,003.7%−19.1%+691% / +375%
RGNXREGENXBIO Inc.509.0 m—-137.6%-112.6%+104.5%−42% / −61%
ALLOAllogene Therapeutics, Inc.411.1 m—-42.4%-3,566.7%−100.0%+7% / −66%
AUTLAutolus Therapeutics plc367.3 m—-133.0%-238.7%+644.9%−2% / −68%
FENCFennec Pharmaceuticals Inc.362.9 m—-18.6%-5.5%−6.1%+26% / +20%
AGENAgenus Inc313.8 m2.6—69.3%+10.4%+53% / −55%
OCGNOcugen, Inc.296.7 m——-1,367.6%+8.8%−29% / +126%
ALECAlector, Inc.254.6 m—-385.1%-850.1%−79.1%+71% / −58%
PLXProtalix BioTherapeutics, Inc.216.7 m11.731.2%23.5%−1.2%+51% / +78%

1- and 3-year price returns: for ALLO from daily closes (the same as the performance table), for the other companies from month-end closes.

olivLaw engine forecast

The world engine ran after the company's latest material disclosure. Probabilities are of TOUCHING a level within the horizon (not closing there) and sit next to the random walk (p_rw), the no-information benchmark.

The engine has no published run for this company yet.

Valuation scenarios (editable assumptions)

Illustrative scenarios

Illustrative: not forecasts and without probabilities. Each case is one coherent set of assumptions, computed on today's figures.

Bear
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
Allowed range: -10 … 20%
Allowed range: 0 … 100%
Base
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
Allowed range: -10 … 20%
Allowed range: 0 … 100%
Bull
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
Allowed range: -10 … 20%
Allowed range: 0 … 100%
Nothing is saved.

Estimated price (USD)

Estimated priceBearBaseBull
1 years
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
3 years
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
5 years
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
What moves the 3-year price the most

    AI analysis

    AI-generatedAI-generated analysis (Claude) from cited public sources; it may contain errors. Not investment advice. As of 27 Oct 2026 · Model: claude-haiku-5-5.

    In brief

    Allogene Therapeutics develops allogeneic 'off-the-shelf' CAR T therapies for cancer and autoimmune disease, with its pivotal ALPHA3 program in first-line large B-cell lymphoma now in focus. The 2026 interim futility analysis showed a higher MRD negativity rate in the cema-cel arm, which keeps investors and specialists watching the program closely.2

    SWOT

    Strengths

    • The company has an allogeneic platform with several clinical programs and its own manufacturing facility for clinical supply.1
    • Interim ALPHA3 data show a clear difference in MRD clearance, with a safety profile that compares favorably with the broader CAR T experience.23
    • FDA RMAT and Fast Track designations may facilitate dialogue with the agency and a faster timeline.

    Weaknesses

    • The company has no approved products and no product revenue, and its losses are recurring.
    • Dependence on external financing is high, and future capital market conditions are uncertain.
    • Programs are at early or intermediate stages, and clinical results for some remain limited.

    Opportunities

    • If ALPHA3 confirms the benefit, MRD-guided consolidation could open a new first-line indication.
    • The Dagger technology could extend use into autoimmune disease, where demand for chemotherapy-free treatments is high.

    Threats

    • If financing is not available on acceptable terms, development could slow or stop.
    • Serious adverse events in trials can lead to suspensions or protocol changes, as already happened in one arm.
    • Competition in CAR T and autoimmune cell therapies could reduce the potential market share.

    Risks

    • Capital requirementshigh

      The company has no committed financing source, and failing to raise funds could delay or end programs.1

    • ALPHA3 trial riskhigh

      The interim futility analysis rests on a small sample, and final event-free survival results are not yet known.2

    • Operational disruptionmedium

      The facility and suppliers, located in areas exposed to earthquakes and fires, could be affected by natural events or other interruptions.1

    • Banking system exposurelow

      Cash is held in banks above insurance limits, and access to those funds could be delayed in a crisis.1

    Investment thesis

    What would need to be true (bull case)

    • If final ALPHA3 data confirm the benefit of consolidation with cema-cel, the company could become the first CAR T therapy used in first line for patients at high risk of relapse.2
    • Immediate availability of an allogeneic product could make administration in community centers, where CAR T experience is limited, more feasible.2
    • The Dagger technology could enable autoimmune treatments without chemotherapy, a difference that could matter commercially.

    What would break the thesis

    • The company may need additional financing before any product revenue, which could lead to significant dilution.
    • Interim results are based on a small number of patients, and final efficacy could differ from what is anticipated.
    • Competition from approved autologous therapies and other allogeneic programs could limit adoption of the product.

    What to watch

    • Reaching about 100 active ALPHA3 sites2026
    • Interim EFS analysis in ALPHA3mid-2027
    • Completion of ALPHA3 enrollment and program financing2027

    Products, market & competition

    AI-generatedAI-generated analysis (Claude) from cited public sources; it may contain errors. Not investment advice. As of 27 Oct 2026 · Model: claude-haiku-5-5.

    The business

    Allogene Therapeutics, Inc. is a clinical-stage immuno-oncology company developing genetically engineered allogeneic T cell product candidates, meaning they are derived from healthy donors for use in any patient, unlike autologous therapies. The company has no products approved for sale and has not generated product revenue to date, and its net loss was $190.9 million for 2025.1 Because of this loss record and an accumulated deficit, operations depend on available capital, which stood at $258.3 million on 31 December 2025.1

    The platform relies on gene-editing technologies, including TALEN and CRISPR, to reduce the risk of graft-versus-host disease, along with the proprietary Dagger technology aimed at reducing the need for standard chemotherapy lymphodepletion. Clinical results for these approaches are still being validated, so their long-term value remains an open question.1

    Segments

    Cema-cel (LBCL, first line)

    Cema-cel is the most advanced candidate and is being evaluated in the pivotal Phase 2 ALPHA3 trial as consolidation after first-line therapy. At the April 2026 interim futility analysis, 58.3% of patients in the cema-cel arm achieved MRD negativity, compared with 16.7% in the observation arm.2 The study is enrolling at more than 80 sites and could reach about 100 sites by the end of 2026.3

    Market context

    The CAR T market already includes approved autologous products, and allogeneic therapies aim to gain ground through immediate availability and scalability. If ALPHA3 data confirm the clinical benefit of MRD-guided consolidation, the product could be used in community cancer centers, where many newly diagnosed patients receive care.1 Access to this market, however, depends on final results and regulatory approvals.2

    Trends

    • Outpatient delivery of CAR Ttailwind

      ALPHA3 data suggest that treatment and monitoring can largely take place in the outpatient setting, even at centers with limited CAR T experience.2 If these results hold, they could widen access to cell therapies.

    • Capital dependence and dilutionheadwind

      The company has no committed source of financing and may need to issue equity or convertible securities, which would dilute shareholders.1 High operating expenses keep this pressure constant.

    Competitive position

    The company competes with approved autologous CAR T therapies, which have demonstrated efficacy but are limited by manufacturing time and logistical complexity. The allogeneic advantage lies in immediate product availability, and in this context the sources indicate the therapy could be administered more broadly.12

    Other developers of allogeneic and cell-based autoimmune therapies may compete for the same patients and development funding. The company acknowledges it may need partners to advance certain programs.1

    • Approved autologous CAR T therapies

      Products already marketed in later-line settings, referenced in the comparison of accessibility and logistics with allogeneic therapy.

    • Allogeneic CAR T developers

      Companies developing similar allogeneic products that may compete for patients and funding, not named in the sources provided.

    • Gene-editing technology licensors

      Suppliers of editing technologies under license to the company; not direct competitors, but they influence timelines and costs.

    News & filings

    In the press

    No news in our archive over the last 180 days.

    SEC filings

    Sources

    1. [1] Form 10-K, fiscal year ended 2025-12-31 · SEC / Allogene Therapeutics, Inc. · 12 Mar 2026
    2. [2] Form 10-Q, quarter ended 2026-06-30 · SEC / Allogene Therapeutics, Inc. · 12 Aug 2026
    3. [3] Form 8-K, results release (exhibit 99.1) · SEC / Allogene Therapeutics, Inc. · 12 Aug 2026

    Figures computed by olivLaw from SEC filings and closing prices; the qualitative analysis is AI-generated from cited sources. Not investment advice.