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olivLaw · European equity research

Valneva SE VLA.PA

France · Euronext Paris · ISIN FR0004056851 · Vertical: Listed companies from France

2.56EUR+0.95% · 1 dayClose 05 Nov 2026

Valneva SE is a French biotechnology company that develops and sells travel and infectious disease vaccines, led by IXIARO, DUKORAL and IXCHIQ. In fiscal 2025 the company reported total revenue of 174.7 mn EUR, but posted a net loss of 115.2 mn EUR as regulatory restrictions weighed on IXCHIQ.

At the close of 05 Nov 2026, Valneva SE (VLA.PA) stock was 2.56 EUR (+0.95% on the day), with market capitalisation 433.0 m EUR, beta 1.02, 52-week range 2.08–5.08 EUR.

Data as of · AI analysis dated · Source: ESEF annual reports and closing prices, computed by olivLaw.

Market cap
433.0 m EUR
shares as of 31 Dec 2025
P/E (TTM)
unavailable
Diluted EPS TTM -0.68 · TTM to 31 Dec 2025
E/P (TTM)
-26.60%
TTM to 31 Dec 2025
Dividend yield
unavailable
Beta (2y)
1.02
Volatility (1y) 71%
52-week range
2.085.08

Price history

Loading chart…

Technical reading

RSI (14)
51.2
neutral
Bollinger (20, 2)
2.34 – 2.65
in the upper half of the band · %B 0.70 · band width 12.1%
SMA 50 / 200
2.66 / 2.90
downtrend (price < SMA50 < SMA200)
MACD (12, 26, 9)
-0.04 / -0.05
MACD above signal

Indicators describe past prices; on their own they do not predict direction. On our history the RSI ≤ 40 filter added no return (see the signals methodology).

Performance

CompanyEURO STOXX 50vs EURO STOXX 50Vertical median
1 month−0.4%−0.6%+0.3 pp—
3 months+15.1%−4.2%+19.3 pp—
6 months+4.3%+4.3%−0.0 pp—
Year to date−31.3%+7.5%−38.8 pp—
1 year−34.0%+9.9%−43.9 pp−6.8%
3 years−55.7%+49.8%−105.6 pp−15.9%
5 years−85.6%+42.8%−128.4 pp—
Max drawdown (1y)
−59.0%
24 Feb 2026 → 23 Jul 2026
Max drawdown (5y)
−93.8%
29 Nov 2021 → 16 Dec 2024
Compound annual growth (5y)
−32.1%
EURO STOXX 50 +7.4%

Price returns, dividends excluded.

Quarterly results

ESEF annual reports carry no quarters: the results are annual (below).

E/P over time

E/P = trailing-12-month diluted EPS / price at quarter end. E/P is the inverse of P/E and stays defined when earnings are negative.

Fiscal years

Fiscal year202320242025
Revenue153.7 m169.6 m174.7 m
Revenue YoYunavailable+10.3%+3.0%
Net income-101.4 m-12.2 m-115.2 m
Net income YoYunavailableunavailableunavailable
Diluted EPS-0.73-0.08-0.68
Diluted EPS YoYunavailableunavailableunavailable
net %-66.0%-7.2%-66.0%
Free cash flow-217.0 m-81.1 m-57.3 m

Balance sheet & financial health

Fiscal year 2025 · 31 Dec 2025

Cash
109.7 m EUR
Financial debt
179.2 m EUR
Net debt
69.5 m EUR
Equity
106.2 m EUR
Total assets
398.8 m EUR
Debt / equity
1.69x
Current ratio
2.38x
ROE
-80.2%
ROA
-25.6%
FCF margin
-32.8%

Financial statements (source on every figure)

Revenue and net income (EUR)

Margins

Income statement · EUR

Revenue
2023
153.7 m
2024
169.6 m
2025
174.7 m

esef· 18 Mar 2026verified

Cost of revenue
2023
100.9 m
2024
98.5 m
2025
107.1 m

esef· 18 Mar 2026verified

Gross profit
2023
52.8 m ≈
2024
71.0 m ≈
2025
67.5 m ≈

esef· 18 Mar 2026derived

Research & development
2023
59.9 m
2024
74.1 m
2025
85.3 m

esef· 18 Mar 2026verified

Operating income
2023
-82.1 m
2024
13.3 m
2025
-82.1 m

esef· 18 Mar 2026verified

Interest expense
2023
23.3 m
2024
24.0 m
2025
41.9 m

esef· 18 Mar 2026verified

Pre-tax income
2023
-98.6 m
2024
-11.5 m
2025
-114.1 m

esef· 18 Mar 2026verified

Income tax
2023
2.8 m
2024
761.0 k
2025
1.1 m

esef· 18 Mar 2026verified

Net income
2023
-101.4 m
2024
-12.2 m
2025
-115.2 m

esef· 18 Mar 2026verified

Diluted EPS
2023
-0.73
2024
-0.08
2025
-0.68

esef· 18 Mar 2026verified

Balance sheet · EUR

Cash
2023
126.1 m
2024
168.3 m
2025
109.7 m

esef· 18 Mar 2026verified

Inventories
2023
44.5 m
2024
53.7 m
2025
50.2 m

esef· 18 Mar 2026verified

Current assets
2023
262.8 m
2024
299.0 m
2025
222.5 m

esef· 18 Mar 2026verified

Property, plant & equipment, net
2023
136.2 m
2024
138.9 m
2025
119.5 m

esef· 18 Mar 2026verified

Intangibles (excl. goodwill)
2023
25.6 m
2024
25.3 m
2025
22.3 m

esef· 18 Mar 2026verified

Total assets
2023
460.1 m
2024
500.0 m
2025
398.8 m

esef· 18 Mar 2026verified

Accounts payable
2023
44.3 m
2024
35.5 m
2025
24.5 m

esef· 18 Mar 2026verified

Short-term debt
2023
44.1 m
2024
20.9 m
2025
17.9 m

esef· 18 Mar 2026verified

Long-term debt
2023
132.8 m
2024
166.5 m
2025
161.3 m

esef· 18 Mar 2026verified

Current liabilities
2023
158.9 m
2024
114.6 m
2025
93.3 m

esef· 18 Mar 2026verified

Total liabilities
2023
331.8 m
2024
318.8 m
2025
292.7 m

esef· 18 Mar 2026verified

Equity
2023
128.2 m
2024
181.3 m
2025
106.2 m

esef· 18 Mar 2026verified

Shares outstanding at year end
2023
138.9 m
2024
153.1 m
2025
169.4 m

esef· 18 Mar 2026derived

Cash flow · EUR

Operating cash flow
2023
-202.7 m
2024
-67.2 m
2025
-52.9 m

esef· 18 Mar 2026verified

Capex
2023
14.2 m
2024
13.9 m
2025
4.4 m

esef· 18 Mar 2026verified

Free cash flow
2023
-217.0 m ≈
2024
-81.1 m ≈
2025
-57.3 m ≈

esef· 18 Mar 2026derived

Investing cash flow
2023
-20.6 m
2024
76.9 m
2025
-1.7 m

esef· 18 Mar 2026verified

Financing cash flow
2023
63.1 m
2024
30.7 m
2025
-621.0 k

esef· 18 Mar 2026verified

Computed indicators

Growth

Revenue growth (YoY)
3.0%
computed by olivLawFY 2025
Revenue CAGR 3Y
unavailable
input data missing
Revenue CAGR 5Y
unavailable
input data missing
EBIT growth (YoY)
-715.6%
computed by olivLawFY 2025
Net income growth (YoY)
unavailable
the base of the ratio is not positive
Net income CAGR 3Y
unavailable
input data missing
Net income CAGR 5Y
unavailable
input data missing
EPS growth (YoY)
unavailable
the base of the ratio is not positive
EPS CAGR 3Y
unavailable
input data missing
EPS CAGR 5Y
unavailable
input data missing
FCF growth (YoY)
unavailable
the base of the ratio is not positive

Profitability

Gross margin
38.7%
computed by olivLawFY 2025
EBITDA margin
unavailable
input data missing
EBIT margin
-47.0%
computed by olivLawFY 2025
Net margin
-66.0%
computed by olivLawFY 2025
FCF margin
-32.8%
computed by olivLawFY 2025

Returns

ROE
-80.2%
computed by olivLawFY 2025 · balance sheet at 31 Dec 2025
ROA
-25.6%
computed by olivLawFY 2025 · balance sheet at 31 Dec 2025
ROIC
-36.7%
computed by olivLawFY 2025 · balance sheet at 31 Dec 2025
ROCE
-26.9%
computed by olivLawFY 2025 · balance sheet at 31 Dec 2025
Payout ratio (EPS)
unavailable
input data missing
Payout ratio (FCF)
unavailable
input data missing

Balance sheet

Net debt
69.5 m EUR
computed by olivLawbalance sheet at 31 Dec 2025
Net debt / EBITDA
unavailable
input data missing
Debt / equity
1.7x
computed by olivLawbalance sheet at 31 Dec 2025
Interest coverage
-2.0x
computed by olivLawFY 2025

Liquidity

Current ratio
2.4x
computed by olivLawbalance sheet at 31 Dec 2025
Quick ratio
1.8x
computed by olivLawbalance sheet at 31 Dec 2025
Cash ratio
1.2x
computed by olivLawbalance sheet at 31 Dec 2025

Cash

Operating cash flow
-52.9 m EUR
computed by olivLawFY 2025
Capital expenditure
4.4 m EUR
computed by olivLawFY 2025
Free cash flow
-57.3 m EUR
computed by olivLawFY 2025
FCF conversion
unavailable
insufficient data
Cash conversion
unavailable
input data missing

Efficiency

Days sales outstanding
unavailable
input data missing
Days inventory outstanding
177 days
computed by olivLawFY 2025 · balance sheet at 31 Dec 2025
Days payables outstanding
102 days
computed by olivLawFY 2025 · balance sheet at 31 Dec 2025
Cash conversion cycle
unavailable
input data missing

Market and valuation

Market capitalisation
433.0 m EUR
computed by olivLawbalance sheet at 31 Dec 2025
Enterprise value
502.5 m EUR
computed by olivLawbalance sheet at 31 Dec 2025
Market cap / net income TTM
unavailable
insufficient data
P/E (TTM)
unavailable
insufficient data
Earnings yield
-26.6%
computed by olivLawFY 2025
P/B
4.1x
computed by olivLawbalance sheet at 31 Dec 2025
P/S
2.5x
computed by olivLawFY 2025 · balance sheet at 31 Dec 2025
EV/EBITDA
unavailable
input data missing
EV/EBIT
unavailable
insufficient data
EV/Sales
2.9x
computed by olivLawFY 2025 · balance sheet at 31 Dec 2025
P/FCF
unavailable
the base of the ratio is not positive
FCF yield
-13.2%
computed by olivLawFY 2025 · balance sheet at 31 Dec 2025
Dividend yield
unavailable
no dividend in the structured statements; a missing line is not a confirmed zero
Shareholder yield (distributions)
unavailable
input data missing

1 indicators that do not apply to the sector.

Valuation

olivLaw classification

Insufficient data
What is missing
  • indicators available: 5 of at least 6
  • score weight coverage: 35.4% of at least 60%
  • valuation methods computed: 0 of at least 1

A scoring methodology on indicators and valuation, not investment advice.

Closing price

2.56 EUR

05 Nov 2026Source: olivLaw, closing series

Market cap: 433.0 m EUR

Key indicators

Market capitalisation
433.0 m EUR
computed by olivLawbalance sheet at 31 Dec 2025
P/E (TTM)
unavailable
insufficient data
P/B
4.1x
computed by olivLawbalance sheet at 31 Dec 2025
EV/EBITDA
unavailable
input data missing
ROE
-80.2%
computed by olivLawFY 2025 · balance sheet at 31 Dec 2025
Net margin
-66.0%
computed by olivLawFY 2025
Revenue growth (YoY)
3.0%
computed by olivLawFY 2025
Dividend yield
unavailable
no dividend in the structured statements; a missing line is not a confirmed zero

Coverage and freshness

28/37 reporting lines present
Latest full fiscal year: 2025
Latest reported period: 31 Dec 2025
Latest balance sheet date: 31 Dec 2025
Share count (cover of the latest filing), as of: 31 Dec 2025
Source: esefpublished 18 Mar 2026
verified 83derived 3

Score by group

35% · Insufficient data

Estimated value range

unavailable — no valuation method could be computed

Valuation assumptions are editorial choices, not measured; beta is not measured.

Valuation methods

  • DCF (discounted cash flow)unavailable · the base of the ratio is not positive
  • Peers: EV/EBITDAunavailable · input data missing
  • Peers: P/Eunavailable · the base of the ratio is not positive
  • Dividend discount (DDM)unavailable · the company pays no dividend: a dividend model needs an explicit initiation assumption

no valuation method could be computed

Assumptions (illustrative, editorial)

Risk-free rate
3.0%
Equity risk premium
5.5%
Beta (default)
1.00
Cost of equity
8.5%
Terminal growth
2.0%

Factor scorecard

Insufficient data

Minimum-evidence gate: indicators available: 5 of at least 6; score weight coverage: 35.4% of at least 60%; valuation methods computed: 0 of at least 1

FactorValueScoreWeight used
ROIC · Quality-36.7%5 (vs peers)29%
Net margin · Quality-66.0%21 (vs peers)18%
FCF conversion · Qualityunavailableunavailable—
Revenue CAGR 3Y · Growthunavailableunavailable—
EPS CAGR 3Y · Growthunavailableunavailable—
Net debt / EBITDA · Balance sheetunavailableunavailable—
Interest coverage · Balance sheet-2.0x0 (on a fixed band)18%
Current ratio · Balance sheet2.4x100 (on a fixed band)12%
P/E (TTM) · Valuationunavailableunavailable—
EV/EBITDA · Valuationunavailableunavailable—
FCF yield · Valuation-13.2%0 (on a fixed band)24%
Shareholder yield (distributions) · Returnsunavailableunavailable—
Payout ratio (FCF) · Returnsunavailableunavailable—

Factors without a value were dropped; the remaining weights were renormalised.

Score groups

  • Balance sheet40/100 · 2/3 factors with a value
  • Growth· partialunavailable · 0/2 factors with a value
  • Quality11/100 · 2/3 factors with a value
  • Returns· partialunavailable · 0/2 factors with a value
  • Valuation· partial0/100 · 1/3 factors with a value

A «partial» group is computed from under half of its weight or from one factor: it is not a full assessment of the group.

Memo

VALNEVA (VLA.PA). Latest full fiscal year: 2025; data up to 2025-12-31.

Figures computed from the financial statements: revenue 174.7 m EUR in 2025; YoY growth 3.0%; net margin -66.0%; ROE -80.2%.

Valuation cannot be computed from the available data.

Insufficient data for a verdict (indicators available: 5 of at least 6; score weight coverage: 35.4% of at least 60%; valuation methods computed: 0 of at least 1).

Text generated deterministically from the figures shown; no language model. Not investment advice.

What supports the thesis

  • Current ratio: 2.4x

What contradicts it

  • ROIC: -36.7%
  • Net margin: -66.0%
  • Interest coverage: -2.0x
  • FCF yield: -13.2%

Not assessed (insufficient data or a ratio without meaning): FCF conversion, Revenue CAGR 3Y, EPS CAGR 3Y, Net debt / EBITDA, P/E (TTM), EV/EBITDA, Shareholder yield (distributions), Payout ratio (FCF).

Versus the vertical median

Listed companies from France · same country · compared with 39 companies

Multiples and returns vs the median

P/E
—
vertical median 18.3x
EV/EBITDA
—
vertical median 6.3x
P/S
2.5x
vertical median 0.5x
above median (+384.3%)
P/B
4.1x
vertical median 1.1x
above median (+286.4%)
ROE
-80.2%
vertical median 4.2%
below median (−2,029.3%)
Net margin
-66.0%
vertical median 1.1%
below median (−5,951.9%)
EBIT margin
-47.0%
vertical median 3.2%
below median (−1,579.3%)
Revenue YoY
3.0%
vertical median 0.6%
above median (+408.9%)
Net debt/EBITDA
—
vertical median -1.2x
Dividend yield
—
vertical median 1.7%

Price rebased to 100 (monthly, 5 years)

Companies in the vertical

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AI.PAL'air Liquide Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude109.3 bn33.212.9%12.2%−2.0%+26% / +32%
AC.PAAccor13.8 bn30.79.6%8.0%+0.6%+6% / +56%
ADP.PAAeroports De Paris11.7 bn34.17.8%5.6%+12.1%−7% / +4%
AKE.PAArkema7.1 bn115.40.9%0.7%−5.0%+12% / −37%
ALO.PAAlstom5.8 bn18.33.1%1.7%+3.7%−51% / −4%
AF.PAAir France - Klm4.3 bn13.6—1.0%+4.8%+20% / +9%
ATE.PAAlten3.1 bn29.54.8%2.6%−1.1%+33% / −29%
BB.PASociete Bic2.7 bn31.35.0%4.1%−4.8%+32% / +5%
ANTIN.PAAntin Infrastructure Partners1.4 bn13.021.9%36.6%−8.1%−24% / −35%
74SW.PA74software792.7 m20.98.9%8.5%+44.8%−13% / +41%
AUB.PAAubay667.4 m17.813.6%6.3%+11.3%+3% / +45%
ASY.PAAssystem507.1 m69.92.5%1.1%+7.4%−19% / −18%
ATO.PAAtos Se483.0 m—-23,400.0%-17.5%−16.5%−45% / −94%
VLA.PAValneva433.0 m—-80.2%-66.0%+3.0%−36% / −52%
ARAMI.PAAramis Group298.8 m15.010.0%0.8%+6.3%−33% / −16%
ARVEN.PAArverne Group246.1 m—-14.0%-115.3%+27.0%+20% / −35%
BGO.PACompagnie Chargeurs Invest189.4 m—-8.6%-5.7%−2.9%unavailable / unavailable
ALCIS.PACatering International & Services145.0 m28.49.3%1.9%+5.8%+39% / +107%
ALCGM.PACegedim144.6 m—-2.6%-1.2%+10.9%−26% / −49%
ATEME.PAAteme144.0 m151.32.8%1.0%+2.2%+82% / +77%
ALHEX.PAHexaom144.0 m6.79.9%2.2%+13.1%−32% / +7%
ALBON.PACompagnie Lebon111.7 m16.54.2%8.8%−17.9%+6% / +8%
ALHYF.PALhyfe75.8 m—-33.4%-570.5%+287.2%unavailable / unavailable
ALFER.PASergeferrari Group61.5 m11.55.1%1.5%+7.4%−33% / −27%
ABEO.PAAbeo60.8 m7.36.9%3.0%+12.6%−13% / −54%

1- and 3-year price returns: for VLA.PA from daily closes (the same as the performance table), for the other companies from month-end closes.

olivLaw engine forecast

The world engine ran after the company's latest material disclosure. Probabilities are of TOUCHING a level within the horizon (not closing there) and sit next to the random walk (p_rw), the no-information benchmark.

The engine has no published run for this company yet.

Valuation scenarios (editable assumptions)

Illustrative scenarios

Illustrative: not forecasts and without probabilities. Each case is one coherent set of assumptions, computed on today's figures.

Bear
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
Allowed range: -10 … 20%
Allowed range: 0 … 100%
Base
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
Allowed range: -10 … 20%
Allowed range: 0 … 100%
Bull
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
Allowed range: -10 … 20%
Allowed range: 0 … 100%
Nothing is saved.

Estimated price (EUR)

Estimated priceBearBaseBull
1 years
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
3 years
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
5 years
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
What moves the 3-year price the most

    AI analysis

    AI-generatedAI-generated analysis (Claude) from cited public sources; it may contain errors. Not investment advice. As of 27 Oct 2026 · Model: claude-haiku-5-5.

    In brief

    Valneva SE is a French biotechnology company that develops and sells travel and infectious disease vaccines, led by IXIARO, DUKORAL and IXCHIQ. In fiscal 2025 the company reported total revenue of 174.7 mn EUR 1, but posted a net loss of 115.2 mn EUR 1 as regulatory restrictions weighed on IXCHIQ.

    SWOT

    Strengths

    • A portfolio of commercial products with recognised brands and stable market positions in the travel segment, such as IXIARO and DUKORAL 1.
    • A proprietary cell platform and a network of patents and trade secrets that protect the core technology 1.
    • Diversified revenue from research, licensing and service contracts, which grew in 2025 1.

    Weaknesses

    • Dependence on a small number of major products and their sales 1.
    • A significant net loss and reliance on external financing, with restrictions imposed by the loan agreement 1.
    • Compliance issues and production batch failures that have affected margins and access to certain markets 1.

    Opportunities

    • Development of vaccine candidates for new indications and licensing deals could bring new revenue 1.
    • Regaining access to regulated markets if compliance issues are resolved and restrictions are lifted 1.
    • Rising demand from travellers and government agencies could support sales 1.

    Threats

    • Use restrictions and authorisation suspensions for IXCHIQ, which could reduce sales in several markets 1.
    • Patent expiry could bring similar products to market and affect sales 1.
    • Currency swings, inflation and customs tariffs could affect costs and profitability 1.

    Risks

    • Dependence on key productshigh

      The company has only three major products on the market, and revenue depends on their performance and on health authority recommendations 1.

    • Restrictions on IXCHIQhigh

      The suspension of the US licence and withdrawal of the US authorisation could have long-lasting effects on sales of the product 1.

    • Production and compliance riskshigh

      The FDA inspection of the Almeida site could limit IXIARO supply to the US market if compliance issues are not resolved 1.

    • Need for additional fundingmedium

      The company could need new funds, and financing terms could be harder to obtain given conditions in financial markets 1.

    • Currency riskmedium

      Revenue in US dollars and costs in pounds sterling and Swedish kronor expose the company to exchange rate fluctuations 1.

    Investment thesis

    What would need to be true (bull case)

    • If IXIARO and DUKORAL sales keep growing on travel industry demand, the company could stabilise revenue despite the problems with IXCHIQ 1.
    • If research projects, including the shigellosis candidate, achieve favourable results, they could open new revenue sources 1.
    • If compliance issues at Almeida are resolved, production capacity could again support revenue growth 1.

    What would break the thesis

    • If IXCHIQ restrictions spread to other markets, revenue could fall further and losses could persist 1.
    • If patent expiry brings similar products to market, sales could be significantly affected 1.
    • If the company cannot obtain financing on acceptable terms, development activities could be constrained 1.

    What to watch

    • Resolution of compliance issues at the Almeida site and the FDA decision on the IXIARO BLA supplement2026
    • IXCHIQ sales trend after use restrictions and the withdrawal of the US authorisationQ1 2026
    • Results of the phase 3 trial for the Lyme disease vaccine candidate2026
    • Funding strategy and compliance with Pharmakon loan covenantsnext 10-K

    Products, market & competition

    AI-generatedAI-generated analysis (Claude) from cited public sources; it may contain errors. Not investment advice. As of 27 Oct 2026 · Model: claude-haiku-5-5.

    The business

    Valneva develops vaccines based on its EB66 cell platform and other proprietary technologies, with three major products on the market: IXIARO, DUKORAL and IXCHIQ 1. The company relies on patents, trademarks and trade secrets; patents linked to the EB66 platform could expire in 2036, subject to the conditions in the registration document 1. Production takes place mainly in Scotland (Livingston and Almeida) and Sweden (Solna), with Vienna handling product release 1.

    Commercial activity depends heavily on the travel industry and on the company's ability to produce in line with demand, and product sales declined slightly in 2025 versus 2024 1. Research and development spending rose in 2025, mainly due to the shigellosis vaccine candidate and phase 4 work on IXCHIQ 1. The company recorded an operating loss in 2025, compared with an operating profit in 2024 that included an exceptional gain from the sale of a priority review voucher 1.

    The financial risk profile is significant: the company could need additional funding, and the Pharmakon loan agreement imposes operating restrictions 1. Currency exposure is high, as sales are largely in US dollars and other currencies while production costs are in pounds sterling and Swedish kronor 1.

    Segments

    IXIARO / JESPECT

    The Japanese encephalitis vaccine sold as IXIARO and JESPECT generated sales of 98.4 mn EUR in 2025, up 4.6 percent on travel market demand 1. Gross margin reached 59.6 percent 1, while output from the new Almeida site could only serve markets outside the United States, as the FDA has not yet approved the supplement for that site 1.

    DUKORAL

    The cholera and ETEC diarrhoea vaccine recorded sales of 31.9 mn EUR in 2025, slightly below 2024 due to currency effects and the transfer of German distribution to CSL Seqirus 1. Gross margin fell to 33.3 percent after batch failures in the last quarter of 2025 1.

    IXCHIQ

    The chikungunya vaccine generated sales of 8.4 mn EUR in 2025 1. Activity was hit by temporary use restrictions, the suspension of the US licence, and the voluntary withdrawal of the US authorisation and IND in January 2026 1. Gross margin was negative 1.

    Market context

    The travel vaccine market is relatively shielded from direct biosimilar substitution because of regulatory complexity and manufacturing processes, although similar products approved through full or abbreviated pathways could open the door to competition 1. Demand depends on health body recommendations, vaccine availability and public confidence in vaccines 1.

    US Department of Defense demand for IXIARO depends on troop rotation frequency, which could influence the volumes ordered 1. Costs and revenues could be affected by inflation, customs tariffs and exchange rate movements 1.

    Trends

    • Use restrictions on IXCHIQheadwind

      Regulators limited use of the IXCHIQ vaccine, which could reduce sales in several markets and affect the product's commercial outlook 1.

    • Growth in travel demandtailwind

      Growth in the travel industry supported sales of IXIARO and DUKORAL, and this factor could keep supporting revenue if international travel stays strong 1.

    • Inflation and cost pressureheadwind

      Persistent inflation and customs tariffs have raised production and distribution costs, and difficulty offsetting them could compress margins 1.

    • Development projects and partnershipsmixed

      Development of vaccine candidates, including against shigellosis and Lyme disease, along with licensing agreements, could generate future revenue, although clinical outcomes are uncertain 1.

    Competitive position

    The company competes with other vaccine makers in travel and infectious disease vaccines, and the launch of new vaccines for the same indications could be seen as more effective or with fewer adverse effects 1. Competition from similar products approved through abbreviated pathways could increase if patents expire 1.

    Valneva depends on a small number of major products, which could leave the company vulnerable if a competitor gains a dominant position in its segments 1.

    • Bavarian Nordic

      Company active in travel and infectious disease vaccines, mentioned as a possible competitor in the vaccine sector; the source provides no details on this company.

    • CSL Seqirus

      Distribution partner for DUKORAL in Germany following the commercial transition described in the report 1.

    • Serum Institute of India

      Supply partner whose agreement was terminated in December 2025, affecting IXCHIQ inventory 1.

    • Makers of similar vaccines

      Companies that could launch similar products through full or abbreviated approval pathways if patents expire 1.

    News & filings

    In the press

    Annual reports (ESEF)

    Sources

    1. [1] Annual report, fiscal year ended 2025-12-31 (ESEF) · SEC / Valneva SE · 31 Dec 2025

    Figures computed by olivLaw from ESEF annual reports and closing prices; the qualitative analysis is AI-generated from cited sources. Not investment advice.

    Valneva SE (VLA.PA): stock, results, valuation and forecast · olivLaw