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olivLaw · US equity research

Pulse Biosciences, Inc. PLSE

Surgical & Medical Instruments & Apparatus · SIC 3841 · Vertical: Surgical & Medical Instruments & Apparatus (SIC 3841)

57.06USD+9.31% · 1 dayClose 04 Nov 2026

Pulse Biosciences develops a nanosecond electrical pulse ablation technology, focused mainly on atrial fibrillation, a market estimated above 3.0 billion USD in electrophysiology. The company is still in a controlled commercial launch with very small revenue, and in 2026 it concentrates resources on its cardiac catheter, which is in a pivotal US study.

At the close of 04 Nov 2026, Pulse Biosciences, Inc. (PLSE) stock was 57.06 USD (+9.31% on the day), with market capitalisation 4.1 bn USD, beta 1.40, 52-week range 12.66–57.06 USD. Latest reported quarter (Q2 2026): revenue of 434.0 k USD, net income of -24.7 m USD, diluted EPS -0.36 USD.

Data as of · AI analysis dated · Source: SEC filings and closing prices, computed by olivLaw.

Market cap
4.1 bn USD
shares as of 31 Jul 2026
P/E (TTM)
unavailable
Diluted EPS TTM -1.08 · TTM to 31 Dec 2025
E/P (TTM)
-1.89%
TTM to 31 Dec 2025
Dividend yield
unavailable
Beta (2y)
1.40
Volatility (1y) 83%
52-week range
12.6657.06

Price history

Loading chart…

Technical reading

RSI (14)
62.6
strong (55–70)
Bollinger (20, 2)
44.87 – 57.73
in the upper half of the band · %B 0.95 · band width 25.1%
SMA 50 / 200
51.35 / 31.95
uptrend (price > SMA50 > SMA200)
MACD (12, 26, 9)
1.24 / 0.81
MACD above signal

Indicators describe past prices; on their own they do not predict direction. On our history the RSI ≤ 40 filter added no return (see the signals methodology).

Performance

CompanyS&P 500vs S&P 500Vertical median
1 month+13.0%−2.0%+15.0 pp—
3 months+50.6%−2.2%+52.7 pp—
6 months+197.0%+4.3%+192.8 pp—
Year to date+315.6%+10.6%+305.0 pp—
1 year+255.3%+10.5%+244.8 pp−5.6%
3 years+1,059.8%+73.7%+986.1 pp+6.7%
5 years+143.8%+61.7%+82.1 pp—
Max drawdown (1y)
−29.5%
18 Feb 2026 → 03 Mar 2026
Max drawdown (5y)
−95.0%
08 Nov 2021 → 30 Aug 2022
Compound annual growth (5y)
+19.5%
S&P 500 +10.1%

Price returns, dividends excluded.

Quarterly results

Latest quarter: Q2 2026 · 30 Jun 2026

Revenue
434.0 k USD
unavailable YoY
Net income
-24.7 m USD
unavailable YoY
Diluted EPS
-0.36
unavailable YoY
net / operating
-5,681.3% / -5,823.0%

Quarterly margins

Quarterly statements · USD

Fiscal yearQ3 '24Q4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26Q2 '26
Revenue000086.0 k264.0 k401.0 k434.0 k
Cost of revenue0000279.0 k260.0 k370.0 k273.0 k
Research & development7.7 m10.7 m10.3 m12.1 m11.4 m10.9 m12.6 m17.0 m
SG&A6.0 m9.6 m7.7 m8.2 m8.8 m7.3 m6.6 m8.5 m
Operating income-13.7 m-20.3 m-18.0 m-20.3 m-20.4 m-18.3 m-19.2 m-25.3 m
Pre-tax income-12.7 m87.8 m-16.8 m-19.2 m————
Income tax0000————
Net income-12.7 m-19.4 m-16.8 m-19.2 m-19.4 m-17.4 m-18.6 m-24.7 m
Diluted EPS-0.21—-0.25-0.28-0.29—-0.27-0.36
Operating cash flow-9.0 m ≈-9.1 m-13.5 m-12.8 m ≈-13.0 m ≈-14.8 m-14.6 m-18.7 m ≈
Capex38.0 k ≈53.0 k45.0 k103.0 k ≈62.0 k ≈105.0 k33.0 k90.0 k ≈

≈ derived quarter (cumulative difference / share-days average)

E/P over time

E/P = trailing-12-month diluted EPS / price at quarter end. E/P is the inverse of P/E and stays defined when earnings are negative.

Fiscal years

Fiscal year20182019202020212022202320242025
Revenueunavailableunavailable01.4 m700.0 k00350.0 k
Revenue YoYunavailableunavailableunavailableunavailable−50.6%−100.0%unavailableunavailable
Net income-37.5 m-47.0 m-49.9 m-63.7 m-58.5 m-42.2 m-53.6 m-72.8 m
Net income YoYunavailableunavailableunavailableunavailableunavailableunavailableunavailableunavailable
Diluted EPSunavailableunavailable-2.14-2.28-1.72-0.85-0.92-1.08
Diluted EPS YoYunavailableunavailableunavailableunavailableunavailableunavailableunavailableunavailable
net %unavailableunavailableunavailable-4,489.4%-8,357.9%unavailableunavailable-20,794.6%
Free cash flow-24.2 m-34.8 m-35.8 m-54.5 m-47.4 m-33.2 m-36.5 m-54.4 m

Reported results vs expectations

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Balance sheet & financial health

Fiscal year 2025 · 31 Dec 2025

Cash
80.7 m USD
Financial debt
unavailable USD
Net debt
unavailable USD
Equity
80.7 m USD
Total assets
94.5 m USD
Debt / equity
unavailable
Current ratio
10.53x
ROE
-74.4%
ROA
-64.1%
FCF margin
-15,553.4%

Financial statements (source on every figure)

Revenue and net income (USD)

Margins

Income statement · USD

Revenue
2023
0
2024
0
2025
350.0 k

SEC (XBRL)· 19 Feb 2026verified

Cost of revenue
2023
0
2024
0
2025
539.0 k

SEC (XBRL)· 19 Feb 2026verified

Gross profit
2023
0 ≈
2024
0 ≈
2025
-189.0 k ≈

SEC (XBRL)· 19 Feb 2026derived

Research & development
2023
27.8 m
2024
32.3 m
2025
44.7 m

SEC (XBRL)· 19 Feb 2026verified

SG&A
2023
—
2024
23.9 m
2025
32.0 m

SEC (XBRL)· 19 Feb 2026verified

Operating income
2023
-43.6 m
2024
-56.3 m
2025
-76.9 m

SEC (XBRL)· 19 Feb 2026verified

Pre-tax income
2023
-42.2 m
2024
53.6 m
2025
72.8 m

SEC (XBRL)· 19 Feb 2026verified

Income tax
2023
0
2024
0
2025
0

SEC (XBRL)· 19 Feb 2026verified

Net income
2023
-42.2 m
2024
-53.6 m
2025
-72.8 m

SEC (XBRL)· 19 Feb 2026verified

Diluted EPS
2023
-0.85
2024
-0.92
2025
-1.08

SEC (XBRL)· 19 Feb 2026verified

Balance sheet · USD

Cash
2023
44.4 m
2024
118.0 m
2025
80.7 m

SEC (XBRL)· 19 Feb 2026verified

Receivables
2023
—
2024
0
2025
274.0 k

SEC (XBRL)· 19 Feb 2026verified

Inventories
2023
—
2024
0
2025
136.0 k

SEC (XBRL)· 19 Feb 2026verified

Current assets
2023
45.3 m
2024
119.4 m
2025
83.4 m

SEC (XBRL)· 19 Feb 2026verified

Property, plant & equipment, net
2023
1.5 m
2024
1.2 m
2025
1.1 m

SEC (XBRL)· 19 Feb 2026verified

Goodwill
2023
2.8 m
2024
2.8 m
2025
2.8 m

SEC (XBRL)· 19 Feb 2026verified

Intangibles (excl. goodwill)
2023
1.9 m
2024
1.2 m
2025
575.0 k

SEC (XBRL)· 19 Feb 2026verified

Total assets
2023
59.2 m
2024
132.5 m
2025
94.5 m

SEC (XBRL)· 19 Feb 2026verified

Accounts payable
2023
1.8 m
2024
1.7 m
2025
2.8 m

SEC (XBRL)· 19 Feb 2026verified

Current liabilities
2023
6.7 m
2024
10.1 m
2025
7.9 m

SEC (XBRL)· 19 Feb 2026verified

Total liabilities
2023
14.8 m
2024
17.6 m
2025
13.9 m

SEC (XBRL)· 19 Feb 2026verified

Equity
2023
44.4 m †
2024
114.9 m †
2025
80.7 m †

SEC (XBRL)· 19 Feb 2026verified

Cash flow · USD

Operating cash flow
2023
-33.0 m
2024
-36.3 m
2025
-54.1 m

SEC (XBRL)· 19 Feb 2026verified

Capex
2023
121.0 k
2024
125.0 k
2025
315.0 k

SEC (XBRL)· 19 Feb 2026verified

Free cash flow
2023
-33.2 m ≈
2024
-36.5 m ≈
2025
-54.4 m ≈

SEC (XBRL)· 19 Feb 2026derived

Investing cash flow
2023
-121.0 k
2024
-125.0 k
2025
-335.0 k

SEC (XBRL)· 19 Feb 2026verified

Financing cash flow
2023
16.4 m
2024
110.1 m
2025
17.2 m

SEC (XBRL)· 19 Feb 2026verified

Computed indicators

Growth

Revenue growth (YoY)
unavailable
the base of the ratio is not positive
Revenue CAGR 3Y
-20.6%
computed by olivLawFY 2022 → FY 2025
Revenue CAGR 5Y
unavailable
the base of the ratio is not positive
EBIT growth (YoY)
unavailable
the base of the ratio is not positive
Net income growth (YoY)
unavailable
the base of the ratio is not positive
Net income CAGR 3Y
unavailable
the base of the ratio is not positive
Net income CAGR 5Y
unavailable
the base of the ratio is not positive
EPS growth (YoY)
unavailable
the base of the ratio is not positive
EPS CAGR 3Y
unavailable
the base of the ratio is not positive
EPS CAGR 5Y
unavailable
the base of the ratio is not positive
FCF growth (YoY)
unavailable
the base of the ratio is not positive

Profitability

Gross margin
0.3%
computed by olivLawTTM to 30 Jun 2026
EBITDA margin
unavailable
input data missing
EBIT margin
-7,007.8%
computed by olivLawTTM to 30 Jun 2026
Net margin
-6,755.8%
computed by olivLawTTM to 30 Jun 2026
FCF margin
-5,180.4%
computed by olivLawTTM to 30 Jun 2026

Returns

ROE
-78.5%
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
ROA
-67.9%
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
ROIC
unavailable
input data missing
ROCE
-79.4%
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
Payout ratio (EPS)
unavailable
input data missing
Payout ratio (FCF)
unavailable
input data missing

Balance sheet

Net debt
unavailable
input data missing
Net debt / EBITDA
unavailable
input data missing
Debt / equity
unavailable
input data missing
Interest coverage
unavailable
input data missing

Liquidity

Current ratio
9.6x
computed by olivLawbalance sheet at 30 Jun 2026
Quick ratio
9.6x
computed by olivLawbalance sheet at 30 Jun 2026
Cash ratio
9.3x
computed by olivLawbalance sheet at 30 Jun 2026

Cash

Operating cash flow
-61.1 m USD
computed by olivLawTTM to 30 Jun 2026
Capital expenditure
290.0 k USD
computed by olivLawTTM to 30 Jun 2026
Free cash flow
-61.4 m USD
computed by olivLawTTM to 30 Jun 2026
FCF conversion
unavailable
insufficient data
Cash conversion
unavailable
input data missing

Efficiency

Days sales outstanding
38 days
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
Days inventory outstanding
44 days
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
Days payables outstanding
861 days
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
Cash conversion cycle
-779 days
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026

Market and valuation

Market capitalisation
4.1 bn USD
computed by olivLawbalance sheet at 30 Jun 2026
Enterprise value
unavailable
input data missing
Market cap / net income TTM
unavailable
insufficient data
P/E (TTM)
unavailable
insufficient data
Earnings yield
-2.0%
computed by olivLawTTM to 30 Jun 2026
P/B
40.9x
computed by olivLawbalance sheet at 30 Jun 2026
P/S
3,434.3x
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
EV/EBITDA
unavailable
input data missing
EV/EBIT
unavailable
input data missing
EV/Sales
unavailable
input data missing
P/FCF
unavailable
the base of the ratio is not positive
FCF yield
-1.5%
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
Dividend yield
unavailable
no dividend in the structured statements; a missing line is not a confirmed zero
Shareholder yield (distributions)
unavailable
input data missing

1 indicators that do not apply to the sector.

Valuation

olivLaw classification

Insufficient data
What is missing
  • indicators available: 4 of at least 6
  • score weight coverage: 27.1% of at least 60%
  • valuation methods computed: 0 of at least 1

A scoring methodology on indicators and valuation, not investment advice.

Closing price

57.06 USD

04 Nov 2026Source: olivLaw, closing series

Market cap: 4.1 bn USD

Key indicators

Market capitalisation
4.1 bn USD
computed by olivLawbalance sheet at 30 Jun 2026
P/E (TTM)
unavailable
insufficient data
P/B
40.9x
computed by olivLawbalance sheet at 30 Jun 2026
EV/EBITDA
unavailable
input data missing
ROE
-78.5%
computed by olivLawTTM to 30 Jun 2026 · balance sheet at 30 Jun 2026
Net margin
-6,755.8%
computed by olivLawTTM to 30 Jun 2026
Revenue growth (YoY)
unavailable
the base of the ratio is not positive
Dividend yield
unavailable
no dividend in the structured statements; a missing line is not a confirmed zero

Coverage and freshness

27/37 reporting lines present
Latest full fiscal year: 2025
Latest reported period: 30 Jun 2026
Latest balance sheet date: 30 Jun 2026
Share count (cover of the latest filing), as of: 31 Jul 2026
Source: SEC (XBRL)published 06 Aug 2026
verified 1209derived 75

Score by group

27% · Insufficient data

Estimated value range

unavailable — no valuation method could be computed

Valuation assumptions are editorial choices, not measured; beta is not measured.

Valuation methods

  • DCF (discounted cash flow)unavailable · input data missing
  • Peers: EV/EBITDAunavailable · net debt missing: EV cannot be bridged to equity (missing debt is not zero)
  • Peers: P/Eunavailable · the base of the ratio is not positive
  • Dividend discount (DDM)unavailable · the company pays no dividend: a dividend model needs an explicit initiation assumption

no valuation method could be computed

Multiple comparisons use the SIC vertical: Surgical & Medical Instruments & Apparatus (SIC 3841)

Classification (SIC) comparables group by industry code, not by economic activity; the direct group is an editorial selection by activity. Members' multiples are on their own trailing twelve months, at their own latest close.

Assumptions (illustrative, editorial)

Risk-free rate
4.3%
Equity risk premium
5.0%
Beta (default)
1.00
Cost of equity
9.3%
Terminal growth
2.5%

Factor scorecard

Insufficient data

Minimum-evidence gate: indicators available: 4 of at least 6; score weight coverage: 27.1% of at least 60%; valuation methods computed: 0 of at least 1

FactorValueScoreWeight used
ROIC · Qualityunavailableunavailable—
Net margin · Quality-6,755.8%0 (vs peers)23%
FCF conversion · Qualityunavailableunavailable—
Revenue CAGR 3Y · Growth-20.6%0 (on a fixed band)31%
EPS CAGR 3Y · Growthunavailableunavailable—
Net debt / EBITDA · Balance sheetunavailableunavailable—
Interest coverage · Balance sheetunavailableunavailable—
Current ratio · Balance sheet9.6x100 (on a fixed band)15%
P/E (TTM) · Valuationunavailableunavailable—
EV/EBITDA · Valuationunavailableunavailable—
FCF yield · Valuation-1.5%0 (on a fixed band)31%
Shareholder yield (distributions) · Returnsunavailableunavailable—
Payout ratio (FCF) · Returnsunavailableunavailable—

Factors without a value were dropped; the remaining weights were renormalised.

Score groups

  • Balance sheet· partial100/100 · 1/3 factors with a value
  • Growth· partial0/100 · 1/2 factors with a value
  • Quality· partial0/100 · 1/3 factors with a value
  • Returns· partialunavailable · 0/2 factors with a value
  • Valuation· partial0/100 · 1/3 factors with a value

A «partial» group is computed from under half of its weight or from one factor: it is not a full assessment of the group.

Memo

Pulse Biosciences, Inc. (PLSE). Latest full fiscal year: 2025; data up to 2026-06-30.

Figures computed from the financial statements: revenue 350.0 k USD in 2025; net margin -6,755.8%; ROE -78.5%.

Valuation cannot be computed from the available data.

Insufficient data for a verdict (indicators available: 4 of at least 6; score weight coverage: 27.1% of at least 60%; valuation methods computed: 0 of at least 1).

Text generated deterministically from the figures shown; no language model. Not investment advice.

What supports the thesis

  • Current ratio: 9.6x

What contradicts it

  • Net margin: -6,755.8%
  • Revenue CAGR 3Y: -20.6%
  • FCF yield: -1.5%

Not assessed (insufficient data or a ratio without meaning): ROIC, FCF conversion, EPS CAGR 3Y, Net debt / EBITDA, Interest coverage, P/E (TTM), EV/EBITDA, Shareholder yield (distributions), Payout ratio (FCF).

Versus the vertical median

Surgical & Medical Instruments & Apparatus (SIC 3841) · same industry (4-digit SIC) · compared with 39 companies

Multiples and returns vs the median

P/E
—
vertical median 32.9x
EV/EBITDA
—
vertical median 16.5x
P/S
3,434.3x
vertical median 3.4x
above median (+101,782.9%)
P/B
40.9x
vertical median 5.0x
above median (+711.5%)
ROE
-78.5%
vertical median -2.8%
below median
Net margin
-6,755.8%
vertical median -4.0%
below median
EBIT margin
-7,007.8%
vertical median -0.8%
below median
Revenue YoY
—
vertical median 12.1%
Net debt/EBITDA
—
vertical median 1.7x
Dividend yield
—
vertical median 1.1%

Price rebased to 100 (monthly, 5 years)

Companies in the vertical

Market capP/EROENet marginRevenue YoY1A / 3A
SYKStryker Corp118.2 bn33.116.0%13.8%+11.2%−16% / +5%
MMM3m Company91.5 bn26.480.8%14.0%+1.5%+3% / +114%
BSXBoston Scientific Corporation63.1 bn18.414.3%16.6%+19.9%−57% / −22%
BDXBecton, Dickinson And Company54.0 bn59.83.8%4.0%+8.2%+30% / +7%
RMDResMed Inc.31.9 bn20.726.4%27.8%+9.9%−11% / +44%
DXCMDexcom, Inc.30.9 bn32.737.7%19.4%+15.6%+31% / −28%
WSTWest Pharmaceutical Services, Inc.28.4 bn45.721.2%18.8%+6.3%+47% / +16%
SOLVSolventum Corporation15.2 bn10.934.0%17.3%+0.9%+5% / unavailable
PENPenumbra, Inc12.7 bn81.210.7%10.1%+17.5%+10% / +45%
GMEDGlobus Medical, Inc.11.7 bn22.311.8%17.0%+16.7%−4% / +94%
TFXTeleflex Incorporated6.4 bn—-28.9%-45.8%+17.2%+31% / −34%
HAEHaemonetics Corporation5.8 bn62.311.2%7.1%−2.0%+57% / +58%
MMSIMerit Medical Systems Inc5.4 bn34.09.8%9.9%+11.8%+5% / +27%
HTFLHeartflow, Inc.4.9 bn——-55.8%+39.9%+75% / unavailable
ICUIIcu Medical Inc4.3 bn144.21.4%1.4%−6.3%+16% / +97%
PLSEPulse Biosciences, Inc.4.1 bn—-78.5%-6,755.8%unavailable+255% / +1,060%
LMATLemaitre Vascular, Inc.2.0 bn30.916.8%25.0%+13.5%+6% / +67%
TNDMTandem Diabetes Care, Inc.1.3 bn—-48.0%-6.1%+7.9%−9% / −6%
IARTIntegra Lifesciences Holdings Corp1.2 bn88.31.2%0.8%+1.5%+13% / −62%
BBNXBeta Bionics, Inc.921.5 m—-23.9%-65.3%+53.9%−46% / unavailable
SSIISs Innovations International, Inc.454.9 m—-26.1%-23.7%+105.7%−66% / unavailable
CARLCarlsmed, Inc.439.3 m—-6,196.9%-57.4%+85.9%−1% / unavailable
BWAYBrainsway Ltd.439.0 m224.25.6%7.1%+29.0%+28% / +258%
EMBCEmbecta Corp.369.4 m4.4—8.6%−3.8%−49% / −64%
CLPTClearPoint Neuro, Inc.325.7 m—-167.5%-79.4%+17.8%−30% / +76%

1- and 3-year price returns: for PLSE from daily closes (the same as the performance table), for the other companies from month-end closes.

olivLaw engine forecast

The world engine ran after the company's latest material disclosure. Probabilities are of TOUCHING a level within the horizon (not closing there) and sit next to the random walk (p_rw), the no-information benchmark.

The engine has no published run for this company yet.

Valuation scenarios (editable assumptions)

Illustrative scenarios

Illustrative: not forecasts and without probabilities. Each case is one coherent set of assumptions, computed on today's figures.

Bear
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
Allowed range: -10 … 20%
Allowed range: 0 … 100%
Base
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
Allowed range: -10 … 20%
Allowed range: 0 … 100%
Bull
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
Allowed range: -10 … 20%
Allowed range: 0 … 100%
Nothing is saved.

Estimated price (USD)

Estimated priceBearBaseBull
1 years
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
3 years
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
5 years
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
What moves the 3-year price the most

    AI analysis

    AI-generatedAI-generated analysis (Claude) from cited public sources; it may contain errors. Not investment advice. As of 27 Oct 2026 · Model: claude-haiku-5-5.

    In brief

    Pulse Biosciences develops a nanosecond electrical pulse ablation technology, focused mainly on atrial fibrillation, a market estimated above 3.0 billion USD in electrophysiology. The company is still in a controlled commercial launch with very small revenue, and in 2026 it concentrates resources on its cardiac catheter, which is in a pivotal US study.

    SWOT

    Strengths

    • The patented technology is protected by issued and pending patents, most granted patents expiring between 2035 and 2042 1.
    • The cardiac device holds Breakthrough Device Designation and is enrolled in the FDA TAP program, which could speed review 1.
    • Catheter clinical data show high procedural success and short procedure times, supporting the product's positioning 2.

    Weaknesses

    • Revenue is very small and the company has reported net losses in every period reviewed 3.
    • Dependence on a single product family and a single platform technology means a setback would affect the whole company 1.
    • Funding relies on equity sales, which can dilute existing shareholders 3.

    Opportunities

    • If pivotal studies finish on time, approval for the cardiac market could open a very large market 1.
    • CE approval for cardiac systems, targeted for 2027, could extend access in Europe 3.
    • Interest in an oncology indication through the papillary thyroid microcarcinoma study could widen the portfolio 3.

    Threats

    • Competitors with approved PFA products could gain market share before the company's technology is available 1.
    • Market and financing conditions could make capital harder to obtain, affecting company plans 1.
    • Regulatory changes or delays in FDA approvals could postpone commercial launch 1.

    Risks

    • Very small revenuehigh

      The company has not generated significant revenue and cannot assure it will become profitable 1.

    • Need for additional fundinghigh

      If funds cannot be raised on acceptable terms, development plans could be scaled back or halted 1.

    • Dependence on one platformmedium

      All activity depends on NPS technology, so any technical or regulatory problem would have major effects 1.

    • Physician adoptionmedium

      Physicians may adopt the product slowly, especially without enough reimbursement evidence and economic benefit data 1.

    • Regulatory approvalsmedium

      Cardiac devices require FDA PMA approval, and delays or extra requirements could postpone commercialization 1.

    Investment thesis

    What would need to be true (bull case)

    • If pivotal studies finish on time and clinical results hold, the company could access a cardiac market far larger than its current revenue 13.
    • Catheter data show high procedural success and fast procedures, which could speed adoption by electrophysiologists 2.
    • Capital raised in 2026 could provide extra time to reach important regulatory milestones 3.

    What would break the thesis

    • Revenue remains nearly absent while losses grow with clinical program spending, which may extend the period without profit 3.
    • Equity-based financing can dilute existing shareholders, and if markets weaken capital could become more expensive 13.
    • Competition from PFA and thermal methods could limit market share even if the company's devices are approved 1.

    What to watch

    • Completion of NANOPULSE-AF enrollment and its resultsQ4 2026
    • Filing of the CE Mark application for cardiac systemssecond half of 2026
    • Evolution of Vybrance system revenueQ4 2026
    • Additional financing through the ATM program and new facilitynext quarterly report

    Products, market & competition

    AI-generatedAI-generated analysis (Claude) from cited public sources; it may contain errors. Not investment advice. As of 27 Oct 2026 · Model: claude-haiku-5-5.

    The business

    Pulse Biosciences is an ablation company using its patented Nano-pulse Stimulation (NPS) technology, also called nsPFA when used to ablate cellular tissue 1. Its nPulse System delivers electrical pulses each less than a millionth of a second long that clear cells nonthermally 1. To date revenue has come entirely from the nPulse System family, and the company has not yet generated significant revenue 1.

    Since 2022 the company has focused on treating atrial fibrillation, after stopping its dermatology applications 1. In March 2026 a strategic realignment prioritized the endocardial catheter and other cardiac devices, reducing investment in cardiac surgery and in sales of the Vybrance system 2.

    The company has financed itself mainly through equity sales and loans, and operating losses are expected to continue for at least several years 1. In the second quarter of 2026 it raised net proceeds through its ATM program, so future financing remains a central factor 3.

    Segments

    nPulse Cardiac Catheter System

    The catheter provides circumferential ablation in a single treatment cycle, which could shorten procedure time compared with thermal methods 1. The pivotal NANOPULSE-AF study, with 12 active sites, has passed the halfway point of enrollment, with completion targeted for early Q4 2026 3.

    Surgical Cardiac Clamp

    The clamp is designed for cardiac surgeons treating atrial fibrillation during surgery 1. The pivotal NANOCLAMP-AF study continues enrollment, with completion expected by the end of the first half of 2027 3.

    Vybrance Percutaneous Electrode System

    Vybrance is the company's first product for soft tissue ablation in surgery and received FDA 510(k) clearance in 2024 1. Second quarter 2026 revenue of 434 thousand USD came mainly from this segment in controlled launch 3.

    Market context

    Atrial fibrillation is a highly prevalent arrhythmia affecting about 43 million people worldwide 1. In the United States about 1.9 million patients are diagnosed annually, and the addressable electrophysiology market is estimated above 3.0 billion USD with long-term double-digit growth 1.

    Standard thermal treatments such as radiofrequency and cryoablation leave room for a nonthermal alternative if clinical data confirm safety and efficacy 1. The market, however, depends on regulatory approvals and reimbursement that remain undefined for the company 2.

    Trends

    • Ageing populationtailwind

      A growing number of older people could expand long-term demand for atrial fibrillation treatment 1.

    • Minimally invasive procedurestailwind

      Physician interest in fast and safe procedures, such as PFA, could favor nsPFA adoption if clinical evidence is convincing 1.

    • Financing costsheadwind

      Armed conflicts and trade tariffs may make it harder to raise capital, which could limit development pace 1.

    • Competition in PFAmixed

      Existing PFA products with longer pulses could set standards before nsPFA is approved, influencing adoption 1.

    Competitive position

    The company presents thermal methods such as radiofrequency and cryoablation as the current standard in cardiac ablation 1. Existing PFA products with longer pulses are also described as direct alternatives for treating atrial fibrillation 1.

    The company notes that new competing technologies could emerge and that alternative technologies may advance faster 1. Its position therefore depends on clinical evidence and on obtaining approvals before rivals 2.

    • Existing PFA products in electrophysiology

      Devices using longer pulses in the microsecond range, seen as the direct alternative to nsPFA in atrial fibrillation treatment 1.

    • Thermal ablation methods (radiofrequency and cryoablation)

      The current standard in the Cox-Maze procedure, against which the company's devices are compared 1.

    • Other ablation technologies that could emerge

      The company warns that new technologies could reduce adoption of its products 1.

    • Other electrophysiology device suppliers

      Competitors that could occupy the same market quickly if they obtain approvals ahead of the company 1.

    News & filings

    In the press

    No news in our archive over the last 180 days.

    SEC filings

    • Current report14 Oct 2026
      Other events · Financial statements and exhibits
    • Current report07 Oct 2026
      Other events · Financial statements and exhibits
    • Current report15 Sept 2026
      Material agreement · Termination of a material agreement · Financial statements and exhibits
    • Current report15 Sept 2026
      Other events · Financial statements and exhibits
    • Current report06 Aug 2026
      Material agreement · Financial statements and exhibits
    • Quarterly report06 Aug 2026
    • Current report06 Aug 2026
      Results of operations · Financial statements and exhibits
    • Current report29 Jul 2026
      Other events · Financial statements and exhibits
    • Current report12 Jun 2026
      Shareholder vote
    • Current report10 Jun 2026
      Other events · Financial statements and exhibits

    Sources

    1. [1] Form 10-K, fiscal year ended 2025-12-31 · SEC / Pulse Biosciences, Inc. · 19 Feb 2026
    2. [2] Form 10-Q, quarter ended 2026-06-30 · SEC / Pulse Biosciences, Inc. · 06 Aug 2026
    3. [3] Form 8-K, results release (exhibit 99.1) · SEC / Pulse Biosciences, Inc. · 06 Aug 2026

    Figures computed by olivLaw from SEC filings and closing prices; the qualitative analysis is AI-generated from cited sources. Not investment advice.