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olivLaw · US equity research

Caris Life Sciences, Inc. CAI

Services-Medical Laboratories · SIC 8071 · Vertical: Services-Medical Laboratories (SIC 8071)

33.22USD+1.13% · 1 dayClose 04 Nov 2026

Caris Life Sciences develops and commercializes precision medicine profiling in oncology, combining next-generation sequencing, artificial intelligence and large clinico-genomic datasets. The company reported strong revenue growth in 2026, and recent launches of early detection and prognostic tests extend its offering beyond traditional tissue testing. Total revenue was 263.7 million USD in the second quarter of 2026, and 2026 guidance sits between 1.03 and 1.04 billion USD.

The AI analysis may be outdated: new filings came after its sources (see the «AI analysis» section).

At the close of 04 Nov 2026, Caris Life Sciences, Inc. (CAI) stock was 33.22 USD (+1.13% on the day), with market capitalisation 9.5 bn USD, P/E 97.6 on diluted EPS of 0.34 USD over the last 12 months, beta 1.41, 52-week range 14.55–36.14 USD. Latest reported quarter (Q3 2026): revenue of 275.4 m USD (+27.0% YoY), net income of 15.3 m USD (−37.3% YoY), diluted EPS 0.05 USD.

Data as of · AI analysis dated · Source: SEC filings and closing prices, computed by olivLaw.

Market cap
9.5 bn USD
shares as of 02 Nov 2026
P/E (TTM)
97.6
Diluted EPS TTM 0.34 · TTM to 30 Sept 2026
E/P (TTM)
1.02%
TTM to 30 Sept 2026
Dividend yield
unavailable
Beta (2y)
1.41
Volatility (1y) 69%
52-week range
14.5536.14

Price history

Loading chart…

Technical reading

RSI (14)
56.8
strong (55–70)
Bollinger (20, 2)
27.75 – 35.96
in the upper half of the band · %B 0.67 · band width 25.7%
SMA 50 / 200
29.52 / 21.67
uptrend (price > SMA50 > SMA200)
MACD (12, 26, 9)
1.31 / 1.37
MACD below signal

Indicators describe past prices; on their own they do not predict direction. On our history the RSI ≤ 40 filter added no return (see the signals methodology).

Performance

CompanyS&P 500vs S&P 500Vertical median
1 month+9.3%−1.1%+10.4 pp—
3 months+101.9%−0.5%+102.4 pp—
6 months+73.7%+4.4%+69.3 pp—
Year to date+23.1%+12.3%+10.8 pp—
1 year+6.5%+13.5%−7.0 pp−3.1%
3 yearsunavailable+76.4%unavailable+69.6%
5 yearsunavailable+63.7%unavailable—
Max drawdown (1y)
−50.2%
05 Nov 2025 → 15 May 2026
Max drawdown (5y)
−63.0%
22 Aug 2025 → 15 May 2026
Compound annual growth (5y)
unavailable
S&P 500 +10.4%

Price returns, dividends excluded.

Quarterly results

Latest quarter: Q3 2026 · 30 Sept 2026

Revenue
275.4 m USD
+27.0% YoY
Net income
15.3 m USD
−37.3% YoY
Diluted EPS
0.05
−37.5% YoY
net / operating
5.5% / 7.0%

Quarterly margins

Quarterly statements · USD

Fiscal yearQ4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26Q2 '26Q3 '26
Revenue129.9 m120.9 m181.4 m216.8 m292.9 m216.2 m263.7 m275.4 m
Research & development27.1 m23.1 m25.0 m21.6 m31.8 m31.3 m32.4 m33.8 m
Operating income-37.0 m-58.0 m-18.0 m32.6 m88.4 m5.3 m26.9 m19.3 m
Depreciation & amortisation9.1 m7.0 m6.4 m4.9 m4.3 m5.1 m6.5 m6.6 m
Interest expense13.3 m12.8 m19.2 m13.5 m11.4 m12.8 m9.2 m9.2 m
Pre-tax income-36.9 m-102.6 m-71.8 m24.3 m82.0 m-644.0 k-614.0 k16.9 m
Income tax00000-134.0 k23.0 k1.6 m
Net income-36.9 m-102.6 m-71.8 m24.3 m82.0 m-510.0 k-637.0 k15.3 m
Diluted EPS-1.04 ≈-3.57-7.970.080.29 ≈0.000.000.05
Operating cash flow-38.9 m-31.3 m7.3 m ≈62.4 m ≈44.8 m32.9 m28.5 m ≈-22.2 m ≈
Capex2.3 m2.7 m1.4 m ≈7.1 m ≈5.1 m10.3 m22.1 m ≈17.5 m ≈
Share repurchases022.0 k0 ≈0 ≈91.0 k021.4 m ≈10.0 m ≈

≈ derived quarter (cumulative difference / share-days average)

E/P over time

E/P = trailing-12-month diluted EPS / price at quarter end. E/P is the inverse of P/E and stays defined when earnings are negative.

Today's P/E sits at the 100 percentile of its own 2-quarter history (min 48.1, median 69.0, max 90.0; quarters with earnings only).

Fiscal years

Fiscal year202320242025
Revenue306.1 m412.3 m812.0 m
Revenue YoYunavailable+34.7%+97.0%
Net income-341.4 m-281.9 m-68.1 m
Net income YoYunavailableunavailableunavailable
Diluted EPS-13.24-10.66-3.22
Diluted EPS YoYunavailableunavailableunavailable
net %-111.5%-68.4%-8.4%
Free cash flow-298.4 m-253.6 m66.9 m

Reported results vs expectations

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Balance sheet & financial health

Fiscal year 2025 · 31 Dec 2025

Cash
796.3 m USD
Financial debt
379.0 m USD
Net debt
-417.3 m USD
Equity
577.3 m USD
Total assets
1.1 bn USD
Debt / equity
0.66x
Current ratio
7.85x
ROE
unavailable
ROA
-9.3%
FCF margin
8.2%

Financial statements (source on every figure)

Revenue and net income (USD)

Margins

Income statement · USD

Revenue
2023
306.1 m
2024
412.3 m
2025
812.0 m

SEC (XBRL)· 03 Mar 2026verified

Research & development
2023
116.9 m
2024
113.9 m
2025
101.6 m

SEC (XBRL)· 03 Mar 2026verified

Operating income
2023
-319.6 m
2024
-257.1 m
2025
45.1 m

SEC (XBRL)· 03 Mar 2026verified

Depreciation & amortisation
2023
49.0 m
2024
48.9 m
2025
22.6 m

SEC (XBRL)· 03 Mar 2026verified

EBITDA
2023
-270.6 m ≈
2024
-208.2 m ≈
2025
67.7 m ≈

SEC (XBRL)· 03 Mar 2026derived

Interest expense
2023
31.6 m
2024
50.0 m
2025
56.9 m

SEC (XBRL)· 03 Mar 2026verified

Pre-tax income
2023
-341.4 m
2024
-281.9 m
2025
-68.1 m

SEC (XBRL)· 03 Mar 2026verified

Income tax
2023
0
2024
0
2025
0

SEC (XBRL)· 03 Mar 2026verified

Net income
2023
-341.4 m
2024
-281.9 m
2025
-68.1 m

SEC (XBRL)· 03 Mar 2026verified

Diluted EPS
2023
-13.24
2024
-10.66
2025
-3.22

SEC (XBRL)· 03 Mar 2026verified

Weighted average diluted shares
2023
34.9 m
2024
35.5 m
2025
167.2 m

SEC (XBRL)· 03 Mar 2026verified

Balance sheet · USD

Cash
2023
—
2024
64.0 m
2025
796.3 m

SEC (XBRL)· 03 Mar 2026verified

Receivables
2023
—
2024
88.2 m
2025
112.1 m

SEC (XBRL)· 03 Mar 2026verified

Current assets
2023
—
2024
215.7 m
2025
997.8 m

SEC (XBRL)· 03 Mar 2026verified

Property, plant & equipment, net
2023
—
2024
67.8 m
2025
63.2 m

SEC (XBRL)· 03 Mar 2026verified

Goodwill
2023
—
2024
19.3 m
2025
19.3 m

SEC (XBRL)· 03 Mar 2026verified

Total assets
2023
—
2024
343.7 m
2025
1.1 bn

SEC (XBRL)· 03 Mar 2026verified

Accounts payable
2023
—
2024
27.8 m
2025
39.2 m

SEC (XBRL)· 03 Mar 2026verified

Short-term debt
2023
—
2024
60.1 m
2025
169.0 k

SEC (XBRL)· 03 Mar 2026verified

Long-term debt
2023
—
2024
319.4 m
2025
378.8 m

SEC (XBRL)· 03 Mar 2026verified

Current liabilities
2023
—
2024
165.4 m
2025
127.1 m

SEC (XBRL)· 03 Mar 2026verified

Total liabilities
2023
—
2024
620.9 m
2025
548.4 m

SEC (XBRL)· 03 Mar 2026verified

Equity
2023
-2.1 bn †
2024
-2.5 bn †
2025
577.3 m †

SEC (XBRL)· 03 Mar 2026verified

Cash flow · USD

Operating cash flow
2023
-276.1 m
2024
-245.2 m
2025
83.2 m

SEC (XBRL)· 03 Mar 2026verified

Capex
2023
22.3 m
2024
8.4 m
2025
16.3 m

SEC (XBRL)· 03 Mar 2026verified

Free cash flow
2023
-298.4 m ≈
2024
-253.6 m ≈
2025
66.9 m ≈

SEC (XBRL)· 03 Mar 2026derived

Investing cash flow
2023
214.8 m
2024
52.9 m
2025
-16.3 m

SEC (XBRL)· 03 Mar 2026verified

Financing cash flow
2023
10.1 m
2024
200.3 m
2025
665.0 m

SEC (XBRL)· 03 Mar 2026verified

Share repurchases
2023
0
2024
0
2025
113.0 k

SEC (XBRL)· 03 Mar 2026verified

Computed indicators

Growth

Revenue growth (YoY)
97.0%
computed by olivLawFY 2025
Revenue CAGR 3Y
unavailable
input data missing
Revenue CAGR 5Y
unavailable
input data missing
EBIT growth (YoY)
unavailable
the base of the ratio is not positive
Net income growth (YoY)
unavailable
the base of the ratio is not positive
Net income CAGR 3Y
unavailable
input data missing
Net income CAGR 5Y
unavailable
input data missing
EPS growth (YoY)
unavailable
the base of the ratio is not positive
EPS CAGR 3Y
unavailable
input data missing
EPS CAGR 5Y
unavailable
input data missing
FCF growth (YoY)
unavailable
the base of the ratio is not positive

Profitability

Gross margin
unavailable
input data missing
EBITDA margin
15.5%
computed by olivLawTTM to 30 Sept 2026
EBIT margin
13.4%
computed by olivLawTTM to 30 Sept 2026
Net margin
9.2%
computed by olivLawTTM to 30 Sept 2026
FCF margin
2.8%
computed by olivLawTTM to 30 Sept 2026

Returns

ROE
17.2%
computed by olivLawTTM to 30 Sept 2026 · balance sheet at 30 Sept 2026
ROA
8.6%
computed by olivLawTTM to 30 Sept 2026 · balance sheet at 30 Sept 2026
ROIC
unavailable
input data missing
ROCE
12.8%
computed by olivLawTTM to 30 Sept 2026 · balance sheet at 30 Sept 2026
Payout ratio (EPS)
unavailable
input data missing
Payout ratio (FCF)
unavailable
input data missing

Balance sheet

Net debt
unavailable
input data missing
Net debt / EBITDA
unavailable
input data missing
Debt / equity
0.6x
computed by olivLawbalance sheet at 30 Sept 2026
Interest coverage
3.3x
computed by olivLawTTM to 30 Sept 2026

Liquidity

Current ratio
6.7x
computed by olivLawbalance sheet at 30 Sept 2026
Quick ratio
unavailable
input data missing
Cash ratio
unavailable
input data missing

Cash

Operating cash flow
83.9 m USD
computed by olivLawTTM to 30 Sept 2026
Capital expenditure
55.0 m USD
computed by olivLawTTM to 30 Sept 2026
Free cash flow
28.9 m USD
computed by olivLawTTM to 30 Sept 2026
FCF conversion
30.1%
computed by olivLawTTM to 30 Sept 2026
Cash conversion
51.7%
computed by olivLawTTM to 30 Sept 2026

Efficiency

Days sales outstanding
28 days
computed by olivLawTTM to 30 Sept 2026 · balance sheet at 30 Sept 2026
Days inventory outstanding
unavailable
input data missing
Days payables outstanding
unavailable
input data missing
Cash conversion cycle
unavailable
input data missing

Market and valuation

Market capitalisation
9.5 bn USD
computed by olivLawbalance sheet at 30 Sept 2026
Enterprise value
unavailable
input data missing
Market cap / net income TTM
99.2x
computed by olivLawTTM to 30 Sept 2026
P/E (TTM)
97.6x
computed by olivLawTTM to 30 Sept 2026
Earnings yield
1.0%
computed by olivLawTTM to 30 Sept 2026
P/B
14.9x
computed by olivLawbalance sheet at 30 Sept 2026
P/S
9.1x
computed by olivLawTTM to 30 Sept 2026 · balance sheet at 30 Sept 2026
EV/EBITDA
unavailable
input data missing
EV/EBIT
unavailable
input data missing
EV/Sales
unavailable
input data missing
P/FCF
329.5x
computed by olivLawTTM to 30 Sept 2026 · balance sheet at 30 Sept 2026
FCF yield
0.3%
computed by olivLawTTM to 30 Sept 2026 · balance sheet at 30 Sept 2026
Dividend yield
unavailable
no dividend in the structured statements; a missing line is not a confirmed zero
Shareholder yield (distributions)
0.3%
computed by olivLawTTM to 30 Sept 2026 · balance sheet at 30 Sept 2026

1 indicators that do not apply to the sector.

Valuation

olivLaw classification

Insufficient data
What is missing
  • score weight coverage: 47.9% of at least 60%

A scoring methodology on indicators and valuation, not investment advice.

Closing price

33.22 USD

04 Nov 2026Source: olivLaw, closing series

Market cap: 9.5 bn USD

Key indicators

Market capitalisation
9.5 bn USD
computed by olivLawbalance sheet at 30 Sept 2026
P/E (TTM)
97.6x
computed by olivLawTTM to 30 Sept 2026
P/B
14.9x
computed by olivLawbalance sheet at 30 Sept 2026
EV/EBITDA
unavailable
input data missing
ROE
17.2%
computed by olivLawTTM to 30 Sept 2026 · balance sheet at 30 Sept 2026
Net margin
9.2%
computed by olivLawTTM to 30 Sept 2026
Revenue growth (YoY)
97.0%
computed by olivLawFY 2025
Dividend yield
unavailable
no dividend in the structured statements; a missing line is not a confirmed zero

Coverage and freshness

29/37 reporting lines present
Latest full fiscal year: 2025
Latest reported period: 30 Sept 2026
Latest balance sheet date: 30 Sept 2026
Share count (cover of the latest filing), as of: 02 Nov 2026
Source: SEC (XBRL)published 04 Nov 2026
verified 351derived 26

Score by group

48% · Insufficient data

Estimated value range

Low
9.87
USD per share
Mid
11.25
USD per share
High
12.37
USD per share
Price: 33.22 USD
The price is above the range
Potential to the central value: -66.1% (value / price − 1)
Margin of safety: -195.3% (1 − price / value)
Agreement between methods: single method · 1 methods used · 1 independent bases

The combined range = the median of the valid methods' low, central and high values; it is not a probability interval and does not cover every result. Envelope of all methods: 9.87 – 12.37 USD.

Valuation assumptions are editorial choices, not measured; beta is not measured.

Method ranges (USD per share)

— — Mid · ▏ Price

Valuation methods

  • DCF (discounted cash flow)unavailable · net debt missing: EV cannot be bridged to equity (missing debt is not zero)
  • Peers: EV/EBITDAunavailable · net debt missing: EV cannot be bridged to equity (missing debt is not zero)
  • Peers: P/E9.87 – 12.37 (Mid 11.25)
    4 companies used · median multiple 33.1x · quartiles 29.0x – 36.3x
    CDNA, DGX, LH, VCYT
  • Dividend discount (DDM)unavailable · the company pays no dividend: a dividend model needs an explicit initiation assumption
Multiple comparisons use the SIC vertical: Services-Medical Laboratories (SIC 8071)

Classification (SIC) comparables group by industry code, not by economic activity; the direct group is an editorial selection by activity. Members' multiples are on their own trailing twelve months, at their own latest close.

Assumptions (illustrative, editorial)

Risk-free rate
4.3%
Equity risk premium
5.0%
Beta (default)
1.00
Cost of equity
9.3%
Terminal growth
2.5%

Factor scorecard

Insufficient data

Minimum-evidence gate: score weight coverage: 47.9% of at least 60%

FactorValueScoreWeight used
ROIC · Qualityunavailableunavailable—
Net margin · Quality9.2%78 (vs peers)13%
FCF conversion · Quality30.1%0 (on a fixed band)13%
Revenue CAGR 3Y · Growthunavailableunavailable—
EPS CAGR 3Y · Growthunavailableunavailable—
Net debt / EBITDA · Balance sheetunavailableunavailable—
Interest coverage · Balance sheet3.3x27 (on a fixed band)13%
Current ratio · Balance sheet6.7x100 (on a fixed band)9%
P/E (TTM) · Valuation97.6x17 (vs peers)22%
EV/EBITDA · Valuationunavailableunavailable—
FCF yield · Valuation0.3%4 (on a fixed band)17%
Shareholder yield (distributions) · Returns0.3%5 (on a fixed band)13%
Payout ratio (FCF) · Returnsunavailableunavailable—

Factors without a value were dropped; the remaining weights were renormalised.

Score groups

  • Balance sheet56/100 · 2/3 factors with a value
  • Growth· partialunavailable · 0/2 factors with a value
  • Quality39/100 · 2/3 factors with a value
  • Returns· partial5/100 · 1/2 factors with a value
  • Valuation11/100 · 2/3 factors with a value

A «partial» group is computed from under half of its weight or from one factor: it is not a full assessment of the group.

Memo

CARIS LIFE SCIENCES, INC. (CAI). Latest full fiscal year: 2025; data up to 2026-09-30.

Figures computed from the financial statements: revenue 812.0 m USD in 2025; YoY growth 97.0%; net margin 9.2%; ROE 17.2%.

The estimated value range is 9.87–12.37 USD per share (median of 1 methods, agreement: single method); assumptions are illustrative. Against the central value of 11.25 USD, the price of 33.22 USD leaves a potential of -66.1% (value / price − 1) and a margin of safety of -195.3% (1 − price / value). The range is the median of the methods' low, central and high values, not a probability interval.

Insufficient data for a verdict (score weight coverage: 47.9% of at least 60%).

Text generated deterministically from the figures shown; no language model. Not investment advice.

What supports the thesis

  • Net margin: 9.2%
  • Current ratio: 6.7x

What contradicts it

  • FCF conversion: 30.1%
  • Interest coverage: 3.3x
  • P/E (TTM): 97.6x
  • FCF yield: 0.3%
  • Shareholder yield (distributions): 0.3%
  • The price is above the estimated value range

Not assessed (insufficient data or a ratio without meaning): ROIC, Revenue CAGR 3Y, EPS CAGR 3Y, Net debt / EBITDA, EV/EBITDA, Payout ratio (FCF).

Versus the vertical median

Services-Medical Laboratories (SIC 8071) · same industry (4-digit SIC) · compared with 23 companies

Multiples and returns vs the median

P/E
97.6x
vertical median 33.1x
above median (+195.3%)
EV/EBITDA
—
vertical median 17.4x
P/S
9.1x
vertical median 2.9x
above median (+211.9%)
P/B
14.9x
vertical median 2.8x
above median (+435.5%)
ROE
17.2%
vertical median -11.2%
above median
Net margin
9.2%
vertical median -10.3%
above median
EBIT margin
13.4%
vertical median -13.4%
above median
Revenue YoY
97.0%
vertical median 13.8%
above median (+602.3%)
Net debt/EBITDA
—
vertical median 2.5x
Dividend yield
—
vertical median 0.8%

Price rebased to 100 (monthly, 5 years)

Companies in the vertical

Market capP/EROENet marginRevenue YoY1A / 3A
NTRANatera, Inc.56.4 bn—-12.5%-7.1%+35.9%+64% / +599%
LHLabcorp Holdings Inc.29.9 bn30.211.4%6.9%+7.2%+37% / +70%
DGXQuest Diagnostics Inc28.1 bn25.515.2%9.5%+11.8%+35% / +86%
GHGuardant Health, Inc.22.6 bn——-38.3%+32.9%+55% / +570%
CAICaris Life Sciences, Inc.9.5 bn97.617.2%9.2%+97.0%+7% / unavailable
GRALGRAIL, Inc.6.4 bn—-16.1%-236.9%+17.2%+30% / unavailable
RDNTRadNet, Inc.6.3 bn—-2.1%-0.9%+11.5%−3% / +142%
CDNACaredx, Inc.4.5 bn35.933.0%25.9%+13.8%+380% / +784%
VCYTVeracyte, Inc.4.2 bn37.58.8%20.4%+16.0%+11% / +105%
FTREFortrea Holdings Inc.2.0 bn—-12.3%-2.6%+1.0%+64% / −29%
PSNLPersonalis, Inc.1.7 bn—-62.1%-147.7%−17.7%+47% / +932%
BLLNBillionToOne, Inc.1.3 bn118.430.2%11.3%+100.0%−13% / unavailable
CSTLCastle Biosciences, Inc.1.1 bn—-4.2%-5.4%+3.7%−11% / +79%
FLGTFulgent Genetics, Inc.541.5 m—-8.0%-26.0%+13.8%−33% / −29%
YDESYD Bio Limited492.0 m—-445.1%-1,392.6%+16.9%−40% / unavailable
BDSXBiodesix, Inc.226.7 m—-540.0%-27.0%+24.1%+160% / −28%
XGNExagen Inc.206.2 m—-113.8%-26.6%+19.7%+8% / +363%
SERASera Prognostics, Inc.59.0 m—-49.7%-34,866.7%+5.2%−39% / +4%
AMSAmerican Shared Hospital Services8.2 m—-7.5%-5.8%−0.9%−43% / −48%
MDXHMdxhealth SA8.0 m—-2,440.4%-31.1%+19.8%−96% / −95%
ACONAclarion, Inc.5.0 m—-59.0%-10,978.5%+65.6%−72% / −100%
ADVBAdvanced Biomed Inc.3.5 m0.484.8%5,231.3%unavailable−75% / unavailable
BGLCBioNexus Gene Lab Corp.2.8 m—-33.7%-82.4%−21.9%−79% / −90%
BNRBurning Rock Biotech Limited0—-10.1%-10.3%+9.2%−41% / +55%

1- and 3-year price returns: for CAI from daily closes (the same as the performance table), for the other companies from month-end closes.

olivLaw engine forecast

The world engine ran after the company's latest material disclosure. Probabilities are of TOUCHING a level within the horizon (not closing there) and sit next to the random walk (p_rw), the no-information benchmark.

The engine has no published run for this company yet.

Valuation scenarios (editable assumptions)

Illustrative scenarios

Illustrative: not forecasts and without probabilities. Each case is one coherent set of assumptions, computed on today's figures.

Bear
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
Allowed range: -10 … 20%
Allowed range: 0 … 100%
Base
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
Allowed range: -10 … 20%
Allowed range: 0 … 100%
Bull
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
Allowed range: -10 … 20%
Allowed range: 0 … 100%
Nothing is saved.

Estimated price (USD)

Estimated priceBearBaseBull
1 years
21.36
Total return -36% · Per year -36%
37.59
Total return 13% · Per year 13%
56.39
Total return 70% · Per year 70%
3 years
25.34
Total return -24% · Per year -9%
49.71
Total return 50% · Per year 14%
81.20
Total return 144% · Per year 35%
5 years
30.05
Total return -10% · Per year -2%
65.75
Total return 98% · Per year 15%
116.92
Total return 252% · Per year 29%
What moves the 3-year price the most
  • Exit P/E± 12.43
  • Net margin± 8.70
  • Annual revenue growth± 6.49
  • Annual dilution± 0.73

AI analysis

AI-generatedAI-generated analysis (Claude) from cited public sources; it may contain errors. Not investment advice. As of 27 Oct 2026 · Model: claude-haiku-5-5.

Possibly outdated: the newest document it read is from 05 Aug 2026; since then the company filed 8-K (04 Nov 2026 · results), 10-Q (04 Nov 2026).

In brief

Caris Life Sciences develops and commercializes precision medicine profiling in oncology, combining next-generation sequencing, artificial intelligence and large clinico-genomic datasets. The company reported strong revenue growth in 2026, and recent launches of early detection and prognostic tests extend its offering beyond traditional tissue testing. Total revenue was 263.7 million USD in the second quarter of 2026, and 2026 guidance sits between 1.03 and 1.04 billion USD.

SWOT

Strengths

  • A large clinico-genomic dataset built from comprehensive profiling of many cases, which supports algorithm development and new solutions 1.
  • Strong growth in case volume and revenue in the second quarter of 2026, with improving gross margins 3.
  • Partnerships with several large biopharma companies that use the company's data in research and development 1.

Weaknesses

  • A history of significant net losses, though the loss in the second quarter of 2026 was close to zero 13.
  • Revenue depends mainly on tissue-based profiling, which makes the company vulnerable to changes in that segment 1.
  • Significant indebtedness and reliance on limited suppliers for sequencers and reagents could complicate operations 1.

Opportunities

  • The launch of Caris Detect and other early detection tests could open a new market segment if clinical adoption is confirmed 23.
  • Expansion into other chronic diseases such as cardiology, neurology and metabolic conditions could diversify the business 1.
  • Growing adoption of blood-based tests and digital tools could support new revenue streams 2.

Threats

  • The market is highly competitive and changes quickly, and new technologies could reduce demand for existing solutions 1.
  • Changes in LDT regulation could affect compliance requirements and market access 1.
  • Unfavorable reimbursement decisions by payers could limit revenue growth 1.

Risks

  • Uncertain profitabilityhigh

    The company cannot guarantee long-term annual GAAP profitability, and expenses rise as it invests in new solutions 1.

  • Dependence on tissue profilinghigh

    Most revenue comes from tissue-based profiling, so lower demand for this product could affect results 1.

  • Payer reimbursementmedium

    Limited broad coverage from payers could restrict access to solutions and revenue growth 1.

  • LDT regulationmedium

    Changes in US LDT regulation could impose new requirements on products sold in this format 1.

  • Data security and compliancemedium

    A cybersecurity incident or breach of privacy rules could lead to penalties and lost revenue 1.

Investment thesis

What would need to be true (bull case)

  • If growth in case volume and higher average selling prices continue, revenue could meet or exceed the updated 2026 guidance 3.
  • Recent launches such as Caris Detect and Caris ChromoSeq could open new market segments if they are adopted clinically 2.
  • The large dataset and pharma partnerships could provide a competitive advantage that is hard to replicate 1.

What would break the thesis

  • If payer coverage does not broaden, revenue growth could slow 1.
  • Intense competition and rapid technological change could reduce the market share of current solutions 1.
  • If profitability does not hold after a record quarter, the company could remain dependent on external financing 13.

What to watch

  • Delivery of 2026 revenue guidance of 1.03 to 1.04 billion USD2026
  • Clinical adoption and reimbursement coverage for Caris DetectQ3 2026
  • Trend in gross margin and net loss in coming quartersQ3 2026

Products, market & competition

AI-generatedAI-generated analysis (Claude) from cited public sources; it may contain errors. Not investment advice. As of 27 Oct 2026 · Model: claude-haiku-5-5.

Possibly outdated: the newest document it read is from 05 Aug 2026; since then the company filed 8-K (04 Nov 2026 · results), 10-Q (04 Nov 2026).

The business

Caris has built a patient-centric TechBio model that links molecular profiling with AI-driven analysis, and its data loop feeds clinical products and biopharma partnerships with companies such as Moderna, AbbVie, Xencor, Merck KGaA and Genentech 1. In the second quarter of 2026, it launched Caris Detect for multi-cancer early detection, Caris ChromoSeq for myeloid malignancies and Caris MI Clarity, an AI-based prognostic tool using computational pathology 23.

Molecular profiling services have been the main revenue source, covering tests ordered by physicians and, to a smaller extent, research services for pharma 1. The company posted net losses in recent years, but in the second quarter of 2026 its net loss was only 0.6 million USD and operating cash flow was positive 3.

Segments

Pharma research and development services

This segment sells data access and bioinformatics services to biopharma and academic partners for target discovery and drug development. The reviewed materials do not give a separate 2026 figure for this segment, so its contribution remains largely undisclosed 12.

Early detection and digital solutions

Caris Detect, launched in the second quarter of 2026, is a blood-based WGS test for early detection of multiple cancers, and Caris MI Clarity is a digital image-based prognostic tool. Both are at an early commercial stage, and their effect on revenue is not yet quantified in the available sources 23.

Market context

Adoption of blood-based tests and digital tools is still developing, and their acceptance by clinical guidelines and payers depends on evidence of clinical utility. If these solutions gain broad acceptance, they could extend the market beyond traditional tissue testing 12.

Trends

  • Falling NGS sequencing coststailwind

    Lower costs of next-generation sequencing make molecular profiling more accessible to the healthcare system, which supports growth in test volumes 1.

  • Adoption of blood-based testingtailwind

    Clinical guidelines are beginning to accept complementary use of liquid and tissue biopsy, which could increase demand for products such as Caris Assure 1.

  • Uncertainty in LDT regulationheadwind

    Regulation of laboratory-developed tests in the United States remains uncertain, and legal changes could affect products sold in this format 1.

  • Pressure on reimbursementmixed

    Coverage and reimbursement by third-party payers are not assured, and pricing differences could affect margins and revenue per case 1.

Competitive position

The precision medicine industry is highly competitive and changes rapidly, with frequent technological breakthroughs, and the company acknowledges it must constantly update its solutions to stay relevant 1. Competition comes from diagnostic laboratories offering genomic testing as well as providers of technology and data to the pharma industry 1.

Caris states its advantage lies in the depth and scale of its dataset, its position as the only genomic profiling company that consistently applies WES and WTS to every eligible sample, and its combination of this data with AI, which new entrants could find difficult to replicate 12.

  • Tissue and blood genomic profiling laboratories

    Competitors offering NGS testing for oncology that may compete for the same ordering physicians; the reviewed sources do not name them individually.

  • Multi-cancer early detection test providers

    Companies developing blood-based tests for early cancer detection, a field into which Caris Detect is now entering.

  • AI and data companies for drug discovery

    Players providing data and analytics for pharma partnerships, competing with Caris research segment.

  • Sequencing technology suppliers

    Makers of next-generation sequencers influence costs and access to technology, though the sources do not name them.

News & filings

In the press

The latest news item in our archive is from 22 Sept 2026; the newest SEC filing is from 04 Nov 2026. The press archive comes from the RSS feeds we follow and does not necessarily cover the latest event — the filings alongside do.

SEC filings

Sources

  1. [1] Form 10-K, fiscal year ended 2025-12-31 · SEC / Caris Life Sciences, Inc. · 03 Mar 2026
  2. [2] Form 10-Q, quarter ended 2026-06-30 · SEC / Caris Life Sciences, Inc. · 05 Aug 2026
  3. [3] Form 8-K, results release (exhibit 99.1) · SEC / Caris Life Sciences, Inc. · 05 Aug 2026

Figures computed by olivLaw from SEC filings and closing prices; the qualitative analysis is AI-generated from cited sources. Not investment advice.