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olivLaw · US equity research

Altimmune, Inc. ALT

Pharmaceutical Preparations · SIC 2834 · Vertical: Pharmaceutical Preparations (SIC 2834)

2.12USD+3.92% · 1 dayClose 04 Nov 2026

Altimmune is a late clinical-stage biopharmaceutical company developing pemvidutide, a balanced glucagon/GLP-1 dual receptor agonist, for serious liver diseases including MASH, alcohol use disorder and alcohol-associated liver disease. Its relevance now comes from the start of the PERFORMA Phase 3 trial in MASH, positive RECLAIM AUD data, and a cash position of $519 million as of June 30, 2026.

At the close of 04 Nov 2026, Altimmune, Inc. (ALT) stock was 2.12 USD (+3.92% on the day), with market capitalisation 412.4 m USD, beta 1.57, 52-week range 2.02–6.18 USD. Latest reported quarter (Q2 2026): net income of -22.8 m USD, diluted EPS -0.12 USD.

Data as of · AI analysis dated · Source: SEC filings and closing prices, computed by olivLaw.

Market cap
412.4 m USD
shares as of 07 Aug 2026
P/E (TTM)
unavailable
Diluted EPS TTM -0.77 · TTM to 30 Jun 2026
E/P (TTM)
-36.27%
TTM to 30 Jun 2026
Dividend yield
unavailable
Beta (2y)
1.57
Volatility (1y) 71%
52-week range
2.026.18

Price history

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Technical reading

RSI (14)
34.8
weak (30–45)
Bollinger (20, 2)
1.86 – 2.61
in the lower half of the band · %B 0.35 · band width 33.4%
SMA 50 / 200
2.76 / 3.25
downtrend (price < SMA50 < SMA200)
MACD (12, 26, 9)
-0.20 / -0.22
MACD above signal

Indicators describe past prices; on their own they do not predict direction. On our history the RSI ≤ 40 filter added no return (see the signals methodology).

Performance

CompanyS&P 500vs S&P 500Vertical median
1 month−20.6%−2.0%−18.6 pp—
3 months−30.0%−2.2%−27.9 pp—
6 months−35.0%+4.3%−39.2 pp—
Year to date−41.3%+10.6%−51.8 pp—
1 year−43.6%+10.5%−54.1 pp+16.6%
3 years−22.6%+73.7%−96.3 pp+16.8%
5 years−80.4%+61.7%−142.2 pp—
Max drawdown (1y)
−67.3%
27 Jan 2026 → 02 Nov 2026
Max drawdown (5y)
−91.0%
02 Sept 2022 → 02 Nov 2026
Compound annual growth (5y)
−27.8%
S&P 500 +10.1%

Price returns, dividends excluded.

Quarterly results

Latest quarter: Q2 2026 · 30 Jun 2026

Revenue
unavailable USD
unavailable YoY
Net income
-22.8 m USD
unavailable YoY
Diluted EPS
-0.12
unavailable YoY
net / operating
unavailable / unavailable

Quarterly margins

Quarterly statements · USD

Fiscal yearQ3 '24Q4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26Q2 '26
Revenue5.0 k5.0 k5.0 k5.0 k5.0 k26.0 k——
Research & development19.8 m19.8 m15.8 m17.2 m15.0 m18.4 m16.2 m18.7 m
Operating income-24.8 m-24.9 m-21.8 m-22.9 m-20.9 m-28.9 m-24.2 m-26.2 m
Interest expense6.0 k1.0 k1.0 k264.0 k495.0 k876.0 k1.1 m1.1 m
Pre-tax income-22.8 m-23.2 m-20.3 m-22.1 m-19.0 m-27.4 m-22.6 m-22.8 m
Income tax0—-681.0 k0 ≈0 ≈0——
Net income-22.8 m-23.2 m-19.6 m-22.1 m-19.0 m-27.4 m-22.6 m-22.8 m
Diluted EPS-0.32-0.33 ≈-0.26-0.27-0.21-0.26 ≈-0.18-0.12
Operating cash flow-27.1 m ≈-18.3 m-16.8 m-19.4 m ≈-11.9 m ≈-19.4 m-20.9 m-24.2 m ≈
Capex————0 ≈1.0 k21.0 k32.0 k ≈

≈ derived quarter (cumulative difference / share-days average)

E/P over time

E/P = trailing-12-month diluted EPS / price at quarter end. E/P is the inverse of P/E and stays defined when earnings are negative.

Fiscal years

Fiscal year201820192020⚠ 20212022202320242025
Revenue10.3 m5.8 m8.2 m4.4 m-68.0 k426.0 k20.0 k41.0 k
Revenue YoY−3.8%−43.8%+41.1%—−101.5%unavailable−95.3%+105.0%
Net income-39.2 m-20.5 m-49.0 m-97.1 m-84.7 m-88.4 m-95.1 m-88.1 m
Net income YoYunavailableunavailableunavailable—unavailableunavailableunavailableunavailable
Diluted EPSunavailableunavailable-1.91-2.35-1.81-1.66-1.34-1.00
Diluted EPS YoYunavailableunavailableunavailable—unavailableunavailableunavailableunavailable
net %-379.2%-353.7%-599.2%-2,201.6%124,577.9%-20,762.2%-475,295.0%-214,861.0%
Free cash flow-10.4 m-9.6 m-34.5 m-90.4 m-62.7 m-75.9 munavailable-67.5 m

The series breaks before 2021: earlier years come from the original reports of the issuer of that time, later years from a subsequent filing that restated the perimeter (a separation, discontinued operations). The year-on-year change across the break is not shown.

Reported results vs expectations

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Balance sheet & financial health

Fiscal year 2025 · 31 Dec 2025

Cash
43.8 m USD
Financial debt
34.3 m USD
Net debt
-9.5 m USD
Equity
224.9 m USD
Total assets
279.9 m USD
Debt / equity
0.15x
Current ratio
18.55x
ROE
-50.6%
ROA
-42.0%
FCF margin
-164,746.3%

Financial statements (source on every figure)

Revenue and net income (USD)

Margins

Income statement · USD

Revenue
2023
426.0 k
2024
20.0 k
2025
41.0 k

SEC (XBRL)· 06 Mar 2026verified

Research & development
2023
65.8 m
2024
82.2 m
2025
66.4 m

SEC (XBRL)· 06 Mar 2026verified

Operating income
2023
-95.9 m
2024
-103.2 m
2025
-94.5 m

SEC (XBRL)· 06 Mar 2026verified

Depreciation & amortisation
2023
—
2024
—
2025
—

SEC (XBRL)· 28 Feb 2023verified

EBITDA
2023
—
2024
—
2025
—

SEC (XBRL)· 28 Feb 2023derived

Interest expense
2023
35.0 k
2024
9.0 k
2025
1.6 m

SEC (XBRL)· 06 Mar 2026verified

Pre-tax income
2023
-88.4 m
2024
-95.1 m
2025
-88.8 m

SEC (XBRL)· 06 Mar 2026verified

Income tax
2023
—
2024
—
2025
-681.0 k

SEC (XBRL)· 06 Mar 2026verified

Net income
2023
-88.4 m
2024
-95.1 m
2025
-88.1 m

SEC (XBRL)· 06 Mar 2026verified

Diluted EPS
2023
-1.66
2024
-1.34
2025
-1.00

SEC (XBRL)· 06 Mar 2026verified

Weighted average diluted shares
2023
53.2 m
2024
71.0 m
2025
88.1 m

SEC (XBRL)· 06 Mar 2026verified

Balance sheet · USD

Cash
2023
135.1 m
2024
36.9 m
2025
43.8 m

SEC (XBRL)· 06 Mar 2026verified

Current assets
2023
209.6 m
2024
137.3 m
2025
278.2 m

SEC (XBRL)· 06 Mar 2026verified

Property, plant & equipment, net
2023
651.0 k
2024
413.0 k
2025
312.0 k

SEC (XBRL)· 06 Mar 2026verified

Intangibles (excl. goodwill)
2023
0
2024
0
2025
—

SEC (XBRL)· 27 Feb 2025verified

Total assets
2023
210.6 m
2024
139.3 m
2025
279.9 m

SEC (XBRL)· 06 Mar 2026verified

Accounts payable
2023
2.1 m
2024
211.0 k
2025
2.7 m

SEC (XBRL)· 06 Mar 2026verified

Long-term debt
2023
—
2024
—
2025
34.3 m

SEC (XBRL)· 06 Mar 2026verified

Current liabilities
2023
12.1 m
2024
10.5 m
2025
15.0 m

SEC (XBRL)· 06 Mar 2026verified

Total liabilities
2023
16.5 m
2024
15.8 m
2025
55.0 m

SEC (XBRL)· 06 Mar 2026verified

Equity
2023
194.1 m †
2024
123.5 m †
2025
224.9 m †

SEC (XBRL)· 06 Mar 2026verified

Cash flow · USD

Operating cash flow
2023
-75.8 m
2024
-79.8 m
2025
-67.5 m

SEC (XBRL)· 06 Mar 2026verified

Capex
2023
47.0 k
2024
—
2025
11.0 k

SEC (XBRL)· 06 Mar 2026verified

Free cash flow
2023
-75.9 m ≈
2024
—
2025
-67.5 m ≈

SEC (XBRL)· 06 Mar 2026derived

Investing cash flow
2023
13.7 m
2024
-28.4 m
2025
-132.5 m

SEC (XBRL)· 06 Mar 2026verified

Financing cash flow
2023
86.1 m
2024
10.0 m
2025
206.8 m

SEC (XBRL)· 06 Mar 2026verified

Computed indicators

Growth

Revenue growth (YoY)
105.0%
computed by olivLawFY 2025
Revenue CAGR 3Y
unavailable
the base of the ratio is not positive
Revenue CAGR 5Y
-65.3%
computed by olivLawFY 2020 → FY 2025
EBIT growth (YoY)
unavailable
the base of the ratio is not positive
Net income growth (YoY)
unavailable
the base of the ratio is not positive
Net income CAGR 3Y
unavailable
the base of the ratio is not positive
Net income CAGR 5Y
unavailable
the base of the ratio is not positive
EPS growth (YoY)
unavailable
the base of the ratio is not positive
EPS CAGR 3Y
unavailable
the base of the ratio is not positive
EPS CAGR 5Y
unavailable
the base of the ratio is not positive
FCF growth (YoY)
unavailable
input data missing

Profitability

Gross margin
unavailable
input data missing
EBITDA margin
unavailable
input data missing
EBIT margin
-244,451.2%
computed by olivLawFY 2025
Net margin
-223,804.9%
computed by olivLawFY 2025
FCF margin
-186,736.6%
computed by olivLawFY 2025

Returns

ROE
-28.9%
computed by olivLawFY 2025 · balance sheet at 30 Jun 2026
ROA
-25.6%
computed by olivLawFY 2025 · balance sheet at 30 Jun 2026
ROIC
-38.4%
computed by olivLawFY 2025 · balance sheet at 30 Jun 2026
ROCE
-19.5%
computed by olivLawFY 2025 · balance sheet at 30 Jun 2026
Payout ratio (EPS)
unavailable
input data missing
Payout ratio (FCF)
unavailable
input data missing

Balance sheet

Net debt
-28.3 m USD
computed by olivLawbalance sheet at 30 Jun 2026
Net debt / EBITDA
unavailable
input data missing
Debt / equity
0.1x
computed by olivLawbalance sheet at 30 Jun 2026
Interest coverage
-28.3x
computed by olivLawFY 2025

Liquidity

Current ratio
26.8x
computed by olivLawbalance sheet at 30 Jun 2026
Quick ratio
unavailable
input data missing
Cash ratio
5.0x
computed by olivLawbalance sheet at 30 Jun 2026

Cash

Operating cash flow
-76.5 m USD
computed by olivLawTTM to 30 Jun 2026
Capital expenditure
54.0 k USD
computed by olivLawTTM to 30 Jun 2026
Free cash flow
-76.6 m USD
computed by olivLawFY 2025
FCF conversion
unavailable
insufficient data
Cash conversion
unavailable
input data missing

Efficiency

Days sales outstanding
unavailable
input data missing
Days inventory outstanding
unavailable
input data missing
Days payables outstanding
unavailable
input data missing
Cash conversion cycle
unavailable
input data missing

Market and valuation

Market capitalisation
412.4 m USD
computed by olivLawbalance sheet at 30 Jun 2026
Enterprise value
384.1 m USD
computed by olivLawbalance sheet at 30 Jun 2026
Market cap / net income TTM
unavailable
insufficient data
P/E (TTM)
unavailable
insufficient data
Earnings yield
-36.3%
computed by olivLawTTM to 30 Jun 2026
P/B
0.9x
computed by olivLawbalance sheet at 30 Jun 2026
P/S
10,058.0x
computed by olivLawFY 2025 · balance sheet at 30 Jun 2026
EV/EBITDA
unavailable
input data missing
EV/EBIT
unavailable
insufficient data
EV/Sales
9,368.6x
computed by olivLawFY 2025 · balance sheet at 30 Jun 2026
P/FCF
unavailable
the base of the ratio is not positive
FCF yield
-18.6%
computed by olivLawFY 2025 · balance sheet at 30 Jun 2026
Dividend yield
unavailable
input data missing
Shareholder yield (distributions)
unavailable
input data missing

1 indicators that do not apply to the sector.

Valuation

olivLaw classification

Insufficient data
What is missing
  • indicators available: 5 of at least 6
  • score weight coverage: 35.4% of at least 60%
  • valuation methods computed: 0 of at least 1

A scoring methodology on indicators and valuation, not investment advice.

Closing price

2.12 USD

04 Nov 2026Source: olivLaw, closing series

Market cap: 412.4 m USD

Key indicators

Market capitalisation
412.4 m USD
computed by olivLawbalance sheet at 30 Jun 2026
P/E (TTM)
unavailable
insufficient data
P/B
0.9x
computed by olivLawbalance sheet at 30 Jun 2026
EV/EBITDA
unavailable
input data missing
ROE
-28.9%
computed by olivLawFY 2025 · balance sheet at 30 Jun 2026
Net margin
-223,804.9%
computed by olivLawFY 2025
Revenue growth (YoY)
105.0%
computed by olivLawFY 2025
Dividend yield
unavailable
input data missing

Coverage and freshness

26/37 reporting lines present
Latest full fiscal year: 2025
Latest reported period: 30 Jun 2026
Latest balance sheet date: 30 Jun 2026
Share count (cover of the latest filing), as of: 07 Aug 2026
Source: SEC (XBRL)published 12 Aug 2026
verified 1883derived 145

Score by group

35% · Insufficient data

Estimated value range

unavailable — no valuation method could be computed

Valuation assumptions are editorial choices, not measured; beta is not measured.

Valuation methods

  • DCF (discounted cash flow)unavailable · the base of the ratio is not positive
  • Peers: EV/EBITDAunavailable · input data missing
  • Peers: P/Eunavailable · the base of the ratio is not positive
  • Dividend discount (DDM)unavailable · input data missing

no valuation method could be computed

Multiple comparisons use the SIC vertical: Pharmaceutical Preparations (SIC 2834)

Classification (SIC) comparables group by industry code, not by economic activity; the direct group is an editorial selection by activity. Members' multiples are on their own trailing twelve months, at their own latest close.

Assumptions (illustrative, editorial)

Risk-free rate
4.3%
Equity risk premium
5.0%
Beta (default)
1.00
Cost of equity
9.3%
Terminal growth
2.5%

Factor scorecard

Insufficient data

Minimum-evidence gate: indicators available: 5 of at least 6; score weight coverage: 35.4% of at least 60%; valuation methods computed: 0 of at least 1

FactorValueScoreWeight used
ROIC · Quality-38.4%25 (vs peers)29%
Net margin · Quality-223,804.9%0 (vs peers)18%
FCF conversion · Qualityunavailableunavailable—
Revenue CAGR 3Y · Growthunavailableunavailable—
EPS CAGR 3Y · Growthunavailableunavailable—
Net debt / EBITDA · Balance sheetunavailableunavailable—
Interest coverage · Balance sheet-28.3x0 (on a fixed band)18%
Current ratio · Balance sheet26.8x100 (on a fixed band)12%
P/E (TTM) · Valuationunavailableunavailable—
EV/EBITDA · Valuationunavailableunavailable—
FCF yield · Valuation-18.6%0 (on a fixed band)24%
Shareholder yield (distributions) · Returnsunavailableunavailable—
Payout ratio (FCF) · Returnsunavailableunavailable—

Factors without a value were dropped; the remaining weights were renormalised.

Score groups

  • Balance sheet40/100 · 2/3 factors with a value
  • Growth· partialunavailable · 0/2 factors with a value
  • Quality16/100 · 2/3 factors with a value
  • Returns· partialunavailable · 0/2 factors with a value
  • Valuation· partial0/100 · 1/3 factors with a value

A «partial» group is computed from under half of its weight or from one factor: it is not a full assessment of the group.

Memo

ALTIMMUNE, INC. (ALT). Latest full fiscal year: 2025; data up to 2026-06-30.

Figures computed from the financial statements: revenue 41.0 k USD in 2025; YoY growth 105.0%; net margin -223,804.9%; ROE -28.9%.

Valuation cannot be computed from the available data.

Insufficient data for a verdict (indicators available: 5 of at least 6; score weight coverage: 35.4% of at least 60%; valuation methods computed: 0 of at least 1).

Text generated deterministically from the figures shown; no language model. Not investment advice.

What supports the thesis

  • Current ratio: 26.8x

What contradicts it

  • ROIC: -38.4%
  • Net margin: -223,804.9%
  • Interest coverage: -28.3x
  • FCF yield: -18.6%

Not assessed (insufficient data or a ratio without meaning): FCF conversion, Revenue CAGR 3Y, EPS CAGR 3Y, Net debt / EBITDA, P/E (TTM), EV/EBITDA, Shareholder yield (distributions), Payout ratio (FCF).

Versus the vertical median

Pharmaceutical Preparations (SIC 2834) · same industry (4-digit SIC) · compared with 39 companies

Multiples and returns vs the median

P/E
—
vertical median 32.4x
EV/EBITDA
—
vertical median 24.9x
P/S
10,058.0x
vertical median 7.1x
above median (+142,480.8%)
P/B
0.9x
vertical median 6.0x
below median (−85.6%)
ROE
-28.9%
vertical median -9.5%
below median
Net margin
-223,804.9%
vertical median 4.2%
below median (−5,344,138.9%)
EBIT margin
-244,451.2%
vertical median -4.2%
below median
Revenue YoY
105.0%
vertical median 5.7%
above median (+1,752.3%)
Net debt/EBITDA
—
vertical median -0.0x
Dividend yield
—
vertical median 2.2%

Price rebased to 100 (monthly, 5 years)

Companies in the vertical

Market capP/EROENet marginRevenue YoY1A / 3A
LLYEli Lilly And Company1,325.9 bn45.786.1%31.9%+44.7%+31% / +138%
JNJJohnson & Johnson640.8 bn40.420.0%16.2%+6.0%+29% / +72%
ONCBeone Medicines Ltd.524.7 bn817.514.7%10.7%+40.2%+4% / +90%
ABBVAbbVie Inc.505.5 bn49.2—15.7%+8.6%+26% / +101%
MRKMerck & Co., Inc.356.9 bn115.67.0%4.8%+1.3%+38% / +41%
ABTAbbott Laboratories190.6 bn30.612.4%13.9%+5.7%−15% / +5%
PFEPfizer Inc171.0 bn42.74.4%6.3%−1.6%+17% / −2%
VRTXVertex Pharmaceuticals Inc134.6 bn34.220.8%30.7%+8.9%+22% / +50%
BMYBristol-Myers Squibb Company126.1 bn13.744.1%18.5%−0.2%+25% / +25%
TEVATeva Pharmaceutical Industries Limited48.9 bn97.66.6%3.6%+4.3%+56% / +327%
ZTSZoetis Inc.34.3 bn13.764.4%27.5%+2.3%−35% / −53%
ROIVRoivant Sciences Ltd.26.0 bn—-6.2%-3,535.0%−71.6%+73% / +277%
UTHRUnited Therapeutics Corporation25.8 bn21.519.3%41.6%+10.6%+24% / +151%
RPRXRoyalty Pharma plc25.8 bn37.68.5%32.1%+5.1%+66% / +145%
INSMInsmed Inc22.9 bn—-72.5%-39.9%+66.7%−50% / +317%
VTRSViatris Inc.21.7 bn—-23.6%-23.9%−3.0%+77% / +106%
ALNYAlnylam Pharmaceuticals, Inc.21.4 bn8.1126.6%52.8%+65.2%−65% / −5%
TGTXTg Therapeutics, Inc.9.4 bn22.5100.3%55.2%+87.3%+85% / +381%
BLRXBioLineRx Ltd4.9 bn—-12.8%-171.7%−95.9%−46% / −97%
BHCBausch Health Companies Inc.3.1 bn——-7.6%+6.7%+31% / +17%
ANABAnaptysbio, Inc.1.4 bn11.5—82.4%+157.0%+71% / +404%
KURAKura Oncology, Inc.677.0 m—-167.7%-384.3%+25.2%−37% / −21%
DMACDiaMedica Therapeutics Inc.580.8 m—-114.6%—unavailable+25% / +341%
PHATPhathom Pharmaceuticals, Inc.461.7 m——-30.2%+216.9%−64% / −19%
ALTAltimmune, Inc.412.4 m—-28.9%-223,804.9%+105.0%−44% / −23%

1- and 3-year price returns: for ALT from daily closes (the same as the performance table), for the other companies from month-end closes.

olivLaw engine forecast

The world engine ran after the company's latest material disclosure. Probabilities are of TOUCHING a level within the horizon (not closing there) and sit next to the random walk (p_rw), the no-information benchmark.

The engine has no published run for this company yet.

Valuation scenarios (editable assumptions)

Illustrative scenarios

Illustrative: not forecasts and without probabilities. Each case is one coherent set of assumptions, computed on today's figures.

Bear
Allowed range: -50 … 50%
Allowed range: -100 … 100%
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Base
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
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Allowed range: 0 … 100%
Bull
Allowed range: -50 … 50%
Allowed range: -100 … 100%
Allowed range: 0 … 100
Allowed range: -10 … 20%
Allowed range: 0 … 100%
Nothing is saved.

Estimated price (USD)

Estimated priceBearBaseBull
1 years
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
3 years
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
5 years
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
insufficient data
Total return unavailable · Per year unavailable
What moves the 3-year price the most

    AI analysis

    AI-generatedAI-generated analysis (Claude) from cited public sources; it may contain errors. Not investment advice. As of 27 Oct 2026 · Model: claude-haiku-5-5.

    In brief

    Altimmune is a late clinical-stage biopharmaceutical company developing pemvidutide, a balanced glucagon/GLP-1 dual receptor agonist, for serious liver diseases including MASH, alcohol use disorder and alcohol-associated liver disease. Its relevance now comes from the start of the PERFORMA Phase 3 trial in MASH, positive RECLAIM AUD data, and a cash position of $519 million as of June 30, 2026 3.

    SWOT

    Strengths

    • The balanced glucagon and GLP-1 dual mechanism gives a differentiated profile with direct liver effects and weight reduction 1.
    • The company holds Breakthrough Therapy Designation and several Fast Track designations, which could speed regulatory review 12.
    • The cash position is solid, and the company raised significant capital in 2026, supporting several clinical programs at once 23.

    Weaknesses

    • The company has no approved products and no product sales, and net losses remain significant from year to year 1.
    • Dependence on a single lead candidate, pemvidutide, exposes the company to the risk of clinical or regulatory failure 1.
    • General and administrative expenses rose in 2026, which could reduce operating efficiency if not controlled 3.

    Opportunities

    • A successful Phase 3 trial in MASH could open a large market, and evidence from AUD and ALD could extend commercial potential 12.
    • Possible partnerships or licensing deals could accelerate development and reduce pressure on equity capital 1.
    • Moving the headquarters to a region with a strong biopharmaceutical presence could help attract talent and create long-term efficiencies 2.

    Threats

    • Competition from large companies with far greater resources could reduce pemvidutide's share if rival molecules reach the market first 1.
    • Tariffs, trade disputes and inflation could raise trial and supply chain costs 1.
    • The need for additional financing could force shareholder dilution or cutbacks in activity if market conditions worsen 1.

    Risks

    • No product revenuehigh

      The company has not generated product sales and does not expect to do so in the foreseeable future, which makes future profitability uncertain 1.

    • Clinical trial riskhigh

      Failure or delay of a Phase 3 trial could fundamentally change the outlook for the lead program 1.

    • Capital requirementsmedium

      Additional funding could be unavailable on acceptable terms, which could force reductions or termination of some programs 1.

    • Macroeconomic uncertaintymedium

      Tariffs, inflation and geopolitical conflicts could disrupt capital markets and supply chains 1.

    • Nasdaq and SEC constraintslow

      Limits on share issuance and the need for shareholder approval could delay or make financing operations more expensive 1.

    Investment thesis

    What would need to be true (bull case)

    • Phase 2 MASH data showing resolution and fibrosis reduction confirmed by non-invasive markers support the idea that the dual mechanism has real potential.
    • Simultaneous progress across three indications, with a positive RECLAIM study and Fast Track status in AUD, could diversify program risk.
    • The cash position after the 2026 offerings provides runway for the Phase 3 program and the ALD data.

    What would break the thesis

    • The company has no product revenue and losses persist, so any clinical delay could put pressure on financing.
    • Competition in MASH is intense, and several advanced molecules could reach the market before pemvidutide.
    • The timeline for ALD and the Phase 3 program remains long, leaving considerable time for execution or regulatory risk.

    What to watch

    • Final topline data from the RESTORE ALD trialsecond half of 2027
    • Outcome of the End-of-Phase 2 meeting with the FDA for AUDnext quarterly report
    • Trend in research, administrative expenses and cash positionQ3 2026

    Products, market & competition

    AI-generatedAI-generated analysis (Claude) from cited public sources; it may contain errors. Not investment advice. As of 27 Oct 2026 · Model: claude-haiku-5-5.

    The business

    Altimmune, Inc. is a late clinical-stage biopharmaceutical company focused on therapies for serious liver diseases. Its lead product, pemvidutide, is a balanced 1:1 glucagon/GLP-1 dual receptor agonist in development for MASH, alcohol use disorder (AUD) and alcohol-associated liver disease (ALD) 1. The company has not yet generated product sales; its historical revenue came from government grants and contracts 1.

    Segments

    Alcohol use disorder (AUD)

    The RECLAIM Phase 2 trial, with approximately 100 patients, met its primary endpoint with a statistically significant reduction in heavy drinking days versus placebo, as reported in July 2026 23. The company intends to request an End-of-Phase 2 meeting with the FDA 2.

    Alcohol-associated liver disease (ALD)

    The RESTORE Phase 2 trial in ALD completed enrollment in July 2026 with approximately 120 patients, and topline data are expected in the second half of 2027 23. The protocol was amended to better evaluate liver benefits after one year of treatment 2.

    Trends

    • Move into Phase 3 in MASHtailwind

      The company has started a pivotal study and the FDA agreed to use an AI pathology tool qualified for MASH trials 12. If the study confirms the Phase 2b results, it could open a path toward accelerated approval.

    • Expansion into AUD and ALDmixed

      Fast Track status for AUD and positive RECLAIM results diversify the portfolio beyond MASH 23. However, final ALD data are not expected until 2027, which leaves timing uncertainty.

    • Economic and trade uncertaintyheadwind

      The company notes that tariffs, trade disputes, inflation and interest rates could raise costs and disrupt supply chains, potentially affecting the budget for clinical trials 1.

    • Access to capitalmixed

      The company raised significant capital in 2026, but could need additional funding if clinical programs expand or market conditions change. Form S-3 limits and shareholder approval requirements could make financing more costly 1.

    Competitive position

    In the AUD segment, competition includes an approved product and generics, as well as new entrants such as mazdutide developed by Eli Lilly, a GLP-1/glucagon dual agonist 1. Altimmune's advantage depends on showing superior safety and efficacy in these indications 1.

    • Eli LillyLLY

      Developing mazdutide, a GLP-1/glucagon dual agonist, and other GLP-1 molecules for MASH and AUD, with substantially greater research resources 1.

    • Madrigal PharmaceuticalsMDGL

      Developing orally administered THR-β agonists for MASH, competing with pemvidutide in the same disease area 1.

    • AlkermesALKS

      Its approved product in the AUD market represents an existing standard of care in this segment 1.

    News & filings

    In the press

    The latest news item in our archive is from 08 Sept 2026; the newest SEC filing is from 29 Oct 2026. The press archive comes from the RSS feeds we follow and does not necessarily cover the latest event — the filings alongside do.

    SEC filings

    Sources

    1. [1] Form 10-K, fiscal year ended 2025-12-31 · SEC / Altimmune, Inc. · 06 Mar 2026
    2. [2] Form 10-Q, quarter ended 2026-06-30 · SEC / Altimmune, Inc. · 12 Aug 2026
    3. [3] Form 8-K, results release (exhibit 99.1) · SEC / Altimmune, Inc. · 12 Aug 2026

    Figures computed by olivLaw from SEC filings and closing prices; the qualitative analysis is AI-generated from cited sources. Not investment advice.